A novel L1CAM isoform with angiogenic activity generated by NOVA2-mediated alternative splicing

The biological players involved in angiogenesis are only partially defined. Here, we report that endothelial cells (ECs) express a novel isoform of the cell-surface adhesion molecule L1CAM, termed L1-ΔTM. The splicing factor NOVA2, which binds directly to L1CAM pre-mRNA, is necessary and sufficient...

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Detalles Bibliográficos
Autores principales: Angiolini, Francesca, Belloni, Elisa, Giordano, Marco, Campioni, Matteo, Forneris, Federico, Paronetto, Maria Paola, Lupia, Michela, Brandas, Chiara, Pradella, Davide, Di Matteo, Anna, Giampietro, Costanza, Jodice, Giovanna, Luise, Chiara, Bertalot, Giovanni, Freddi, Stefano, Malinverno, Matteo, Irimia, Manuel, Moulton, Jon D, Summerton, James, Chiapparino, Antonella, Ghilardi, Carmen, Giavazzi, Raffaella, Nyqvist, Daniel, Gabellini, Davide, Dejana, Elisabetta, Cavallaro, Ugo, Ghigna, Claudia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398979/
https://www.ncbi.nlm.nih.gov/pubmed/30829570
http://dx.doi.org/10.7554/eLife.44305

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