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Potential Implications of Long Noncoding RNAs in Autoimmune Diseases

Long noncoding RNAs (lncRNAs) are non-protein coding RNAs of more than 200 nucleotides in length. Despite the term “noncoding”, lncRNAs have been reported to be involved in gene expression. Accumulating evidence suggests that lncRNAs play crucial roles in the regulation of immune system and the deve...

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Detalles Bibliográficos
Autores principales: Hur, Keun, Kim, Sang-Hyon, Kim, Ji-Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Association of Immunologists 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399094/
https://www.ncbi.nlm.nih.gov/pubmed/30838159
http://dx.doi.org/10.4110/in.2019.19.e4
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author Hur, Keun
Kim, Sang-Hyon
Kim, Ji-Min
author_facet Hur, Keun
Kim, Sang-Hyon
Kim, Ji-Min
author_sort Hur, Keun
collection PubMed
description Long noncoding RNAs (lncRNAs) are non-protein coding RNAs of more than 200 nucleotides in length. Despite the term “noncoding”, lncRNAs have been reported to be involved in gene expression. Accumulating evidence suggests that lncRNAs play crucial roles in the regulation of immune system and the development of autoimmunity. lncRNAs are expressed in various immune cells including T lymphocytes, B lymphocytes, macrophages, neutrophils, dendritic cells, and NK cells, and are also involved in the differentiation and activation of these immune cells. Here, we review recent studies on the role of lncRNAs in immune regulation and the differential expression of lncRNAs in various autoimmune diseases.
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spelling pubmed-63990942019-03-05 Potential Implications of Long Noncoding RNAs in Autoimmune Diseases Hur, Keun Kim, Sang-Hyon Kim, Ji-Min Immune Netw Review Article Long noncoding RNAs (lncRNAs) are non-protein coding RNAs of more than 200 nucleotides in length. Despite the term “noncoding”, lncRNAs have been reported to be involved in gene expression. Accumulating evidence suggests that lncRNAs play crucial roles in the regulation of immune system and the development of autoimmunity. lncRNAs are expressed in various immune cells including T lymphocytes, B lymphocytes, macrophages, neutrophils, dendritic cells, and NK cells, and are also involved in the differentiation and activation of these immune cells. Here, we review recent studies on the role of lncRNAs in immune regulation and the differential expression of lncRNAs in various autoimmune diseases. The Korean Association of Immunologists 2019-02-25 /pmc/articles/PMC6399094/ /pubmed/30838159 http://dx.doi.org/10.4110/in.2019.19.e4 Text en Copyright © 2019. The Korean Association of Immunologists https://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Hur, Keun
Kim, Sang-Hyon
Kim, Ji-Min
Potential Implications of Long Noncoding RNAs in Autoimmune Diseases
title Potential Implications of Long Noncoding RNAs in Autoimmune Diseases
title_full Potential Implications of Long Noncoding RNAs in Autoimmune Diseases
title_fullStr Potential Implications of Long Noncoding RNAs in Autoimmune Diseases
title_full_unstemmed Potential Implications of Long Noncoding RNAs in Autoimmune Diseases
title_short Potential Implications of Long Noncoding RNAs in Autoimmune Diseases
title_sort potential implications of long noncoding rnas in autoimmune diseases
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399094/
https://www.ncbi.nlm.nih.gov/pubmed/30838159
http://dx.doi.org/10.4110/in.2019.19.e4
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