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Venom-Derived Peptide Modulators of Cation-Selective Channels: Friend, Foe or Frenemy

Ion channels play a key role in our body to regulate homeostasis and conduct electrical signals. With the help of advances in structural biology, as well as the discovery of numerous channel modulators derived from animal toxins, we are moving toward a better understanding of the function and mode o...

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Autores principales: Bajaj, Saumya, Han, Jingyao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399158/
https://www.ncbi.nlm.nih.gov/pubmed/30863305
http://dx.doi.org/10.3389/fphar.2019.00058
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author Bajaj, Saumya
Han, Jingyao
author_facet Bajaj, Saumya
Han, Jingyao
author_sort Bajaj, Saumya
collection PubMed
description Ion channels play a key role in our body to regulate homeostasis and conduct electrical signals. With the help of advances in structural biology, as well as the discovery of numerous channel modulators derived from animal toxins, we are moving toward a better understanding of the function and mode of action of ion channels. Their ubiquitous tissue distribution and the physiological relevancies of their opening and closing suggest that cation channels are particularly attractive drug targets, and years of research has revealed a variety of natural toxins that bind to these channels and alter their function. In this review, we provide an introductory overview of the major cation ion channels: potassium channels, sodium channels and calcium channels, describe their venom-derived peptide modulators, and how these peptides provide great research and therapeutic value to both basic and translational medical research.
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spelling pubmed-63991582019-03-12 Venom-Derived Peptide Modulators of Cation-Selective Channels: Friend, Foe or Frenemy Bajaj, Saumya Han, Jingyao Front Pharmacol Pharmacology Ion channels play a key role in our body to regulate homeostasis and conduct electrical signals. With the help of advances in structural biology, as well as the discovery of numerous channel modulators derived from animal toxins, we are moving toward a better understanding of the function and mode of action of ion channels. Their ubiquitous tissue distribution and the physiological relevancies of their opening and closing suggest that cation channels are particularly attractive drug targets, and years of research has revealed a variety of natural toxins that bind to these channels and alter their function. In this review, we provide an introductory overview of the major cation ion channels: potassium channels, sodium channels and calcium channels, describe their venom-derived peptide modulators, and how these peptides provide great research and therapeutic value to both basic and translational medical research. Frontiers Media S.A. 2019-02-26 /pmc/articles/PMC6399158/ /pubmed/30863305 http://dx.doi.org/10.3389/fphar.2019.00058 Text en Copyright © 2019 Bajaj and Han. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Bajaj, Saumya
Han, Jingyao
Venom-Derived Peptide Modulators of Cation-Selective Channels: Friend, Foe or Frenemy
title Venom-Derived Peptide Modulators of Cation-Selective Channels: Friend, Foe or Frenemy
title_full Venom-Derived Peptide Modulators of Cation-Selective Channels: Friend, Foe or Frenemy
title_fullStr Venom-Derived Peptide Modulators of Cation-Selective Channels: Friend, Foe or Frenemy
title_full_unstemmed Venom-Derived Peptide Modulators of Cation-Selective Channels: Friend, Foe or Frenemy
title_short Venom-Derived Peptide Modulators of Cation-Selective Channels: Friend, Foe or Frenemy
title_sort venom-derived peptide modulators of cation-selective channels: friend, foe or frenemy
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399158/
https://www.ncbi.nlm.nih.gov/pubmed/30863305
http://dx.doi.org/10.3389/fphar.2019.00058
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