Blocking α(2)δ-1 Subunit Reduces Bladder Hypersensitivity and Inflammation in a Cystitis Mouse Model by Decreasing NF-kB Pathway Activation

Bladder pain is frequently associated with bladder inflammation, as in conditions like interstitial cystitis (IC), for which current analgesic therapies have limited efficacy. The antinociceptive effect of alpha-2-delta (α(2)δ) ligands on inflammation-associated visceral pain like that experienced i...

Descripción completa

Detalles Bibliográficos
Autores principales: Boudieu, Ludivine, Mountadem, Sarah, Lashermes, Amandine, Meleine, Mathieu, Ulmann, Lauriane, Rassendren, François, Aissouni, Youssef, Sion, Benoit, Carvalho, Frédéric Antonio, Ardid, Denis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399165/
https://www.ncbi.nlm.nih.gov/pubmed/30863309
http://dx.doi.org/10.3389/fphar.2019.00133

Ejemplares similares

Ejemplares similares