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Reduced habit-driven errors in Parkinson’s Disease
Parkinson’s Disease can be understood as a disorder of motor habits. A prediction of this theory is that early stage Parkinson’s patients will display fewer errors caused by interference from previously over-learned behaviours. We test this prediction in the domain of skilled typing, where actions a...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399280/ https://www.ncbi.nlm.nih.gov/pubmed/30833640 http://dx.doi.org/10.1038/s41598-019-39294-z |
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author | Bannard, Colin Leriche, Mariana Bandmann, Oliver Brown, Christopher H. Ferracane, Elisa Sánchez-Ferro, Álvaro Obeso, José Redgrave, Peter Stafford, Tom |
author_facet | Bannard, Colin Leriche, Mariana Bandmann, Oliver Brown, Christopher H. Ferracane, Elisa Sánchez-Ferro, Álvaro Obeso, José Redgrave, Peter Stafford, Tom |
author_sort | Bannard, Colin |
collection | PubMed |
description | Parkinson’s Disease can be understood as a disorder of motor habits. A prediction of this theory is that early stage Parkinson’s patients will display fewer errors caused by interference from previously over-learned behaviours. We test this prediction in the domain of skilled typing, where actions are easy to record and errors easy to identify. We describe a method for categorizing errors as simple motor errors or habit-driven errors. We test Spanish and English participants with and without Parkinson’s, and show that indeed patients make fewer habit errors than healthy controls, and, further, that classification of error type increases the accuracy of discriminating between patients and healthy controls. As well as being a validation of a theory-led prediction, these results offer promise for automated, enhanced and early diagnosis of Parkinson’s Disease. |
format | Online Article Text |
id | pubmed-6399280 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-63992802019-03-07 Reduced habit-driven errors in Parkinson’s Disease Bannard, Colin Leriche, Mariana Bandmann, Oliver Brown, Christopher H. Ferracane, Elisa Sánchez-Ferro, Álvaro Obeso, José Redgrave, Peter Stafford, Tom Sci Rep Article Parkinson’s Disease can be understood as a disorder of motor habits. A prediction of this theory is that early stage Parkinson’s patients will display fewer errors caused by interference from previously over-learned behaviours. We test this prediction in the domain of skilled typing, where actions are easy to record and errors easy to identify. We describe a method for categorizing errors as simple motor errors or habit-driven errors. We test Spanish and English participants with and without Parkinson’s, and show that indeed patients make fewer habit errors than healthy controls, and, further, that classification of error type increases the accuracy of discriminating between patients and healthy controls. As well as being a validation of a theory-led prediction, these results offer promise for automated, enhanced and early diagnosis of Parkinson’s Disease. Nature Publishing Group UK 2019-03-04 /pmc/articles/PMC6399280/ /pubmed/30833640 http://dx.doi.org/10.1038/s41598-019-39294-z Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Bannard, Colin Leriche, Mariana Bandmann, Oliver Brown, Christopher H. Ferracane, Elisa Sánchez-Ferro, Álvaro Obeso, José Redgrave, Peter Stafford, Tom Reduced habit-driven errors in Parkinson’s Disease |
title | Reduced habit-driven errors in Parkinson’s Disease |
title_full | Reduced habit-driven errors in Parkinson’s Disease |
title_fullStr | Reduced habit-driven errors in Parkinson’s Disease |
title_full_unstemmed | Reduced habit-driven errors in Parkinson’s Disease |
title_short | Reduced habit-driven errors in Parkinson’s Disease |
title_sort | reduced habit-driven errors in parkinson’s disease |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399280/ https://www.ncbi.nlm.nih.gov/pubmed/30833640 http://dx.doi.org/10.1038/s41598-019-39294-z |
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