Cargando…

Reduced habit-driven errors in Parkinson’s Disease

Parkinson’s Disease can be understood as a disorder of motor habits. A prediction of this theory is that early stage Parkinson’s patients will display fewer errors caused by interference from previously over-learned behaviours. We test this prediction in the domain of skilled typing, where actions a...

Descripción completa

Detalles Bibliográficos
Autores principales: Bannard, Colin, Leriche, Mariana, Bandmann, Oliver, Brown, Christopher H., Ferracane, Elisa, Sánchez-Ferro, Álvaro, Obeso, José, Redgrave, Peter, Stafford, Tom
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399280/
https://www.ncbi.nlm.nih.gov/pubmed/30833640
http://dx.doi.org/10.1038/s41598-019-39294-z
_version_ 1783399725921206272
author Bannard, Colin
Leriche, Mariana
Bandmann, Oliver
Brown, Christopher H.
Ferracane, Elisa
Sánchez-Ferro, Álvaro
Obeso, José
Redgrave, Peter
Stafford, Tom
author_facet Bannard, Colin
Leriche, Mariana
Bandmann, Oliver
Brown, Christopher H.
Ferracane, Elisa
Sánchez-Ferro, Álvaro
Obeso, José
Redgrave, Peter
Stafford, Tom
author_sort Bannard, Colin
collection PubMed
description Parkinson’s Disease can be understood as a disorder of motor habits. A prediction of this theory is that early stage Parkinson’s patients will display fewer errors caused by interference from previously over-learned behaviours. We test this prediction in the domain of skilled typing, where actions are easy to record and errors easy to identify. We describe a method for categorizing errors as simple motor errors or habit-driven errors. We test Spanish and English participants with and without Parkinson’s, and show that indeed patients make fewer habit errors than healthy controls, and, further, that classification of error type increases the accuracy of discriminating between patients and healthy controls. As well as being a validation of a theory-led prediction, these results offer promise for automated, enhanced and early diagnosis of Parkinson’s Disease.
format Online
Article
Text
id pubmed-6399280
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-63992802019-03-07 Reduced habit-driven errors in Parkinson’s Disease Bannard, Colin Leriche, Mariana Bandmann, Oliver Brown, Christopher H. Ferracane, Elisa Sánchez-Ferro, Álvaro Obeso, José Redgrave, Peter Stafford, Tom Sci Rep Article Parkinson’s Disease can be understood as a disorder of motor habits. A prediction of this theory is that early stage Parkinson’s patients will display fewer errors caused by interference from previously over-learned behaviours. We test this prediction in the domain of skilled typing, where actions are easy to record and errors easy to identify. We describe a method for categorizing errors as simple motor errors or habit-driven errors. We test Spanish and English participants with and without Parkinson’s, and show that indeed patients make fewer habit errors than healthy controls, and, further, that classification of error type increases the accuracy of discriminating between patients and healthy controls. As well as being a validation of a theory-led prediction, these results offer promise for automated, enhanced and early diagnosis of Parkinson’s Disease. Nature Publishing Group UK 2019-03-04 /pmc/articles/PMC6399280/ /pubmed/30833640 http://dx.doi.org/10.1038/s41598-019-39294-z Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Bannard, Colin
Leriche, Mariana
Bandmann, Oliver
Brown, Christopher H.
Ferracane, Elisa
Sánchez-Ferro, Álvaro
Obeso, José
Redgrave, Peter
Stafford, Tom
Reduced habit-driven errors in Parkinson’s Disease
title Reduced habit-driven errors in Parkinson’s Disease
title_full Reduced habit-driven errors in Parkinson’s Disease
title_fullStr Reduced habit-driven errors in Parkinson’s Disease
title_full_unstemmed Reduced habit-driven errors in Parkinson’s Disease
title_short Reduced habit-driven errors in Parkinson’s Disease
title_sort reduced habit-driven errors in parkinson’s disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399280/
https://www.ncbi.nlm.nih.gov/pubmed/30833640
http://dx.doi.org/10.1038/s41598-019-39294-z
work_keys_str_mv AT bannardcolin reducedhabitdrivenerrorsinparkinsonsdisease
AT lerichemariana reducedhabitdrivenerrorsinparkinsonsdisease
AT bandmannoliver reducedhabitdrivenerrorsinparkinsonsdisease
AT brownchristopherh reducedhabitdrivenerrorsinparkinsonsdisease
AT ferracaneelisa reducedhabitdrivenerrorsinparkinsonsdisease
AT sanchezferroalvaro reducedhabitdrivenerrorsinparkinsonsdisease
AT obesojose reducedhabitdrivenerrorsinparkinsonsdisease
AT redgravepeter reducedhabitdrivenerrorsinparkinsonsdisease
AT staffordtom reducedhabitdrivenerrorsinparkinsonsdisease