Helical antimicrobial peptides assemble into protofibril scaffolds that present ordered dsDNA to TLR9

Amphiphilicity in ɑ-helical antimicrobial peptides (AMPs) is recognized as a signature of potential membrane activity. Some AMPs are also strongly immunomodulatory: LL37-DNA complexes potently amplify Toll-like receptor 9 (TLR9) activation in immune cells and exacerbate autoimmune diseases. The rule...

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Detalles Bibliográficos
Autores principales: Lee, Ernest Y., Zhang, Changsheng, Di Domizio, Jeremy, Jin, Fan, Connell, Will, Hung, Mandy, Malkoff, Nicolas, Veksler, Veronica, Gilliet, Michel, Ren, Pengyu, Wong, Gerard C. L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399285/
https://www.ncbi.nlm.nih.gov/pubmed/30833557
http://dx.doi.org/10.1038/s41467-019-08868-w

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