HER2 and p95HER2 differentially regulate miRNA expression in MCF-7 breast cancer cells and downregulate MYB proteins through miR-221/222 and miR-503

The HER2 oncogene and its truncated form p95HER2 play central roles in breast cancer. Here, we show that although HER2 and p95HER2 generally elicit qualitatively similar changes in miRNA profile in MCF-7 breast cancer cells, a subset of changes are distinct and p95HER2 shifts the miRNA profile towar...

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Detalles Bibliográficos
Autores principales: Gorbatenko, Andrej, Søkilde, Rolf, Sorensen, Ester E., Newie, Inga, Persson, Helena, Morancho, Beatriz, Arribas, Joaquin, Litman, Thomas, Rovira, Carlos, Pedersen, Stine Falsig
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399295/
https://www.ncbi.nlm.nih.gov/pubmed/30833639
http://dx.doi.org/10.1038/s41598-019-39733-x

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