Pocket similarity identifies selective estrogen receptor modulators as microtubule modulators at the taxane site

Taxanes are a family of natural products with a broad spectrum of anticancer activity. This activity is mediated by interaction with the taxane site of beta-tubulin, leading to microtubule stabilization and cell death. Although widely used in the treatment of breast cancer and other malignancies, ex...

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Detalles Bibliográficos
Autores principales: Lo, Yu-Chen, Cormier, Olga, Liu, Tianyun, Nettles, Kendall W., Katzenellenbogen, John A., Stearns, Tim, Altman, Russ B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399299/
https://www.ncbi.nlm.nih.gov/pubmed/30833575
http://dx.doi.org/10.1038/s41467-019-08965-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399299/
https://www.ncbi.nlm.nih.gov/pubmed/30833575
http://dx.doi.org/10.1038/s41467-019-08965-w

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