Green Protocols in Heterocycle Syntheses via 1,3-Dipolar Cycloadditions

The aim of this review is to provide an overview of green protocols for the organic synthesis of heterocycles via 1,3-dipolar cycloaddition. Particular attention has been devoted to the use of green solvents; reactions performed in ionic liquids, fluorinated solvents and water have been included. Al...

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Autores principales: Martina, Katia, Tagliapietra, Silvia, Veselov, Valery V., Cravotto, Giancarlo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399308/
https://www.ncbi.nlm.nih.gov/pubmed/30863745
http://dx.doi.org/10.3389/fchem.2019.00095
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author Martina, Katia
Tagliapietra, Silvia
Veselov, Valery V.
Cravotto, Giancarlo
author_facet Martina, Katia
Tagliapietra, Silvia
Veselov, Valery V.
Cravotto, Giancarlo
author_sort Martina, Katia
collection PubMed
description The aim of this review is to provide an overview of green protocols for the organic synthesis of heterocycles via 1,3-dipolar cycloaddition. Particular attention has been devoted to the use of green solvents; reactions performed in ionic liquids, fluorinated solvents and water have been included. Also explored are several protocols that make use of catalyst-free reaction conditions, the use of microwave irradiation and activation by light exposure. Improvements over commonly used organic solvents will be underlined in order to highlight environmental protection aspects and enhancements in regio- and stereo-selectivity.
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spelling pubmed-63993082019-03-12 Green Protocols in Heterocycle Syntheses via 1,3-Dipolar Cycloadditions Martina, Katia Tagliapietra, Silvia Veselov, Valery V. Cravotto, Giancarlo Front Chem Chemistry The aim of this review is to provide an overview of green protocols for the organic synthesis of heterocycles via 1,3-dipolar cycloaddition. Particular attention has been devoted to the use of green solvents; reactions performed in ionic liquids, fluorinated solvents and water have been included. Also explored are several protocols that make use of catalyst-free reaction conditions, the use of microwave irradiation and activation by light exposure. Improvements over commonly used organic solvents will be underlined in order to highlight environmental protection aspects and enhancements in regio- and stereo-selectivity. Frontiers Media S.A. 2019-02-26 /pmc/articles/PMC6399308/ /pubmed/30863745 http://dx.doi.org/10.3389/fchem.2019.00095 Text en Copyright © 2019 Martina, Tagliapietra, Veselov and Cravotto. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Chemistry
Martina, Katia
Tagliapietra, Silvia
Veselov, Valery V.
Cravotto, Giancarlo
Green Protocols in Heterocycle Syntheses via 1,3-Dipolar Cycloadditions
title Green Protocols in Heterocycle Syntheses via 1,3-Dipolar Cycloadditions
title_full Green Protocols in Heterocycle Syntheses via 1,3-Dipolar Cycloadditions
title_fullStr Green Protocols in Heterocycle Syntheses via 1,3-Dipolar Cycloadditions
title_full_unstemmed Green Protocols in Heterocycle Syntheses via 1,3-Dipolar Cycloadditions
title_short Green Protocols in Heterocycle Syntheses via 1,3-Dipolar Cycloadditions
title_sort green protocols in heterocycle syntheses via 1,3-dipolar cycloadditions
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399308/
https://www.ncbi.nlm.nih.gov/pubmed/30863745
http://dx.doi.org/10.3389/fchem.2019.00095
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