TNFRSF receptor-specific antibody fusion proteins with targeting controlled FcγR-independent agonistic activity

Antibodies specific for TNFRSF receptors that bind soluble ligands without getting properly activated generally act as strong agonists upon FcγR binding. Systematic analyses revealed that the FcγR dependency of such antibodies to act as potent agonists is largely independent from isotype, FcγR type,...

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Detalles Bibliográficos
Autores principales: Medler, Juliane, Nelke, Johannes, Weisenberger, Daniela, Steinfatt, Tim, Rothaug, Moritz, Berr, Susanne, Hünig, Thomas, Beilhack, Andreas, Wajant, Harald
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399339/
https://www.ncbi.nlm.nih.gov/pubmed/30833543
http://dx.doi.org/10.1038/s41419-019-1456-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399339/
https://www.ncbi.nlm.nih.gov/pubmed/30833543
http://dx.doi.org/10.1038/s41419-019-1456-x

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