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TNFRSF receptor-specific antibody fusion proteins with targeting controlled FcγR-independent agonistic activity
Antibodies specific for TNFRSF receptors that bind soluble ligands without getting properly activated generally act as strong agonists upon FcγR binding. Systematic analyses revealed that the FcγR dependency of such antibodies to act as potent agonists is largely independent from isotype, FcγR type,...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399339/ https://www.ncbi.nlm.nih.gov/pubmed/30833543 http://dx.doi.org/10.1038/s41419-019-1456-x |