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Dynamics of Water Diffusion Changes in Different Tissue Compartments From Acute to Chronic Stroke—A Serial Diffusion Tensor Imaging Study

Background and Purpose: The immediate decrease of the apparent diffusion coefficient (ADC) is the main characteristic change of water diffusion in acute ischemic stroke. There is only limited information on the time course of diffusion parameters in different tissue compartments of cerebral ischemia...

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Autores principales: Alegiani, Anna Christina, MacLean, Simon, Braass, Hanna, Gellißen, Susanne, Cho, Tae-Hee, Derex, Laurent, Hermier, Marc, Berthezene, Yves, Nighoghossian, Norbert, Gerloff, Christian, Fiehler, Jens, Thomalla, Götz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399390/
https://www.ncbi.nlm.nih.gov/pubmed/30863361
http://dx.doi.org/10.3389/fneur.2019.00158
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author Alegiani, Anna Christina
MacLean, Simon
Braass, Hanna
Gellißen, Susanne
Cho, Tae-Hee
Derex, Laurent
Hermier, Marc
Berthezene, Yves
Nighoghossian, Norbert
Gerloff, Christian
Fiehler, Jens
Thomalla, Götz
author_facet Alegiani, Anna Christina
MacLean, Simon
Braass, Hanna
Gellißen, Susanne
Cho, Tae-Hee
Derex, Laurent
Hermier, Marc
Berthezene, Yves
Nighoghossian, Norbert
Gerloff, Christian
Fiehler, Jens
Thomalla, Götz
author_sort Alegiani, Anna Christina
collection PubMed
description Background and Purpose: The immediate decrease of the apparent diffusion coefficient (ADC) is the main characteristic change of water diffusion in acute ischemic stroke. There is only limited information on the time course of diffusion parameters in different tissue compartments of cerebral ischemia. Materials and Methods: In a longitudinal study, we examined 21 patients with acute ischemic stroke by diffusion tensor imaging within 5 h after symptom onset, 3 h later, 2 days, and 1 month after symptom onset. Acute diffusion lesion and the fluid-attenuated inversion recovery (FLAIR) after 2 days were used as volumes of interest to define persistent core, lesion growth, and reversible acute diffusion lesion. For all diffusion parameters ratios between the stroke lesion VOIs and the mirror VOIs were calculated for each time point. ADC ratio, fractional anisotropy ratios, and eigenvalues ratios were measured in these volumes of interest and in contralateral mirror regions at each time points. Results: In the persistent core, ADC ratio (0.772) and all eigenvalues ratios were reduced on admission up to 1 day after stroke and increased after 1 month (ADC ratio 1.067). Within the region of infarct growth time course of diffusion parameter changes was similar, but delayed. In the brain area with reversible diffusion lesion, a partial normalization of diffusion parameters over the time was observed, while after 1 month diffusion parameters did not show the signature of healthy brain tissue. There were significantly different trends for all parameters over time between the three tissue compartments. Conclusion: Diffusion tensor imaging displays characteristic changes of water diffusion in different tissue compartments over time in acute ischemic stroke. Even regions with reversible diffusion lesion show diffusion signatures of persisting tissue alterations.
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spelling pubmed-63993902019-03-12 Dynamics of Water Diffusion Changes in Different Tissue Compartments From Acute to Chronic Stroke—A Serial Diffusion Tensor Imaging Study Alegiani, Anna Christina MacLean, Simon Braass, Hanna Gellißen, Susanne Cho, Tae-Hee Derex, Laurent Hermier, Marc Berthezene, Yves Nighoghossian, Norbert Gerloff, Christian Fiehler, Jens Thomalla, Götz Front Neurol Neurology Background and Purpose: The immediate decrease of the apparent diffusion coefficient (ADC) is the main characteristic change of water diffusion in acute ischemic stroke. There is only limited information on the time course of diffusion parameters in different tissue compartments of cerebral ischemia. Materials and Methods: In a longitudinal study, we examined 21 patients with acute ischemic stroke by diffusion tensor imaging within 5 h after symptom onset, 3 h later, 2 days, and 1 month after symptom onset. Acute diffusion lesion and the fluid-attenuated inversion recovery (FLAIR) after 2 days were used as volumes of interest to define persistent core, lesion growth, and reversible acute diffusion lesion. For all diffusion parameters ratios between the stroke lesion VOIs and the mirror VOIs were calculated for each time point. ADC ratio, fractional anisotropy ratios, and eigenvalues ratios were measured in these volumes of interest and in contralateral mirror regions at each time points. Results: In the persistent core, ADC ratio (0.772) and all eigenvalues ratios were reduced on admission up to 1 day after stroke and increased after 1 month (ADC ratio 1.067). Within the region of infarct growth time course of diffusion parameter changes was similar, but delayed. In the brain area with reversible diffusion lesion, a partial normalization of diffusion parameters over the time was observed, while after 1 month diffusion parameters did not show the signature of healthy brain tissue. There were significantly different trends for all parameters over time between the three tissue compartments. Conclusion: Diffusion tensor imaging displays characteristic changes of water diffusion in different tissue compartments over time in acute ischemic stroke. Even regions with reversible diffusion lesion show diffusion signatures of persisting tissue alterations. Frontiers Media S.A. 2019-02-26 /pmc/articles/PMC6399390/ /pubmed/30863361 http://dx.doi.org/10.3389/fneur.2019.00158 Text en Copyright © 2019 Alegiani, MacLean, Braass, Gellißen, Cho, Derex, Hermier, Berthezene, Nighoghossian, Gerloff, Fiehler and Thomalla. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Alegiani, Anna Christina
MacLean, Simon
Braass, Hanna
Gellißen, Susanne
Cho, Tae-Hee
Derex, Laurent
Hermier, Marc
Berthezene, Yves
Nighoghossian, Norbert
Gerloff, Christian
Fiehler, Jens
Thomalla, Götz
Dynamics of Water Diffusion Changes in Different Tissue Compartments From Acute to Chronic Stroke—A Serial Diffusion Tensor Imaging Study
title Dynamics of Water Diffusion Changes in Different Tissue Compartments From Acute to Chronic Stroke—A Serial Diffusion Tensor Imaging Study
title_full Dynamics of Water Diffusion Changes in Different Tissue Compartments From Acute to Chronic Stroke—A Serial Diffusion Tensor Imaging Study
title_fullStr Dynamics of Water Diffusion Changes in Different Tissue Compartments From Acute to Chronic Stroke—A Serial Diffusion Tensor Imaging Study
title_full_unstemmed Dynamics of Water Diffusion Changes in Different Tissue Compartments From Acute to Chronic Stroke—A Serial Diffusion Tensor Imaging Study
title_short Dynamics of Water Diffusion Changes in Different Tissue Compartments From Acute to Chronic Stroke—A Serial Diffusion Tensor Imaging Study
title_sort dynamics of water diffusion changes in different tissue compartments from acute to chronic stroke—a serial diffusion tensor imaging study
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399390/
https://www.ncbi.nlm.nih.gov/pubmed/30863361
http://dx.doi.org/10.3389/fneur.2019.00158
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