Direct Diagnostic Tests for Lyme Disease

Borrelia burgdorferi was discovered to be the cause of Lyme disease in 1983, leading to seroassays. The 1994 serodiagnostic testing guidelines predated a full understanding of key B. burgdorferi antigens and have a number of shortcomings. These serologic tests cannot distinguish active infection, pa...

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Autores principales: Schutzer, Steven E, Body, Barbara A, Boyle, Jeff, Branson, Bernard M, Dattwyler, Raymond J, Fikrig, Erol, Gerald, Noel J, Gomes-Solecki, Maria, Kintrup, Martin, Ledizet, Michel, Levin, Andrew E, Lewinski, Michael, Liotta, Lance A, Marques, Adriana, Mead, Paul S, Mongodin, Emmanuel F, Pillai, Segaran, Rao, Prasad, Robinson, William H, Roth, Kristian M, Schriefer, Martin E, Slezak, Thomas, Snyder, Jessica L, Steere, Allen C, Witkowski, Jan, Wong, Susan J, Branda, John A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Viewpoints
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399434/
https://www.ncbi.nlm.nih.gov/pubmed/30307486
http://dx.doi.org/10.1093/cid/ciy614
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author Schutzer, Steven E
Body, Barbara A
Boyle, Jeff
Branson, Bernard M
Dattwyler, Raymond J
Fikrig, Erol
Gerald, Noel J
Gomes-Solecki, Maria
Kintrup, Martin
Ledizet, Michel
Levin, Andrew E
Lewinski, Michael
Liotta, Lance A
Marques, Adriana
Mead, Paul S
Mongodin, Emmanuel F
Pillai, Segaran
Rao, Prasad
Robinson, William H
Roth, Kristian M
Schriefer, Martin E
Slezak, Thomas
Snyder, Jessica L
Steere, Allen C
Witkowski, Jan
Wong, Susan J
Branda, John A
author_facet Schutzer, Steven E
Body, Barbara A
Boyle, Jeff
Branson, Bernard M
Dattwyler, Raymond J
Fikrig, Erol
Gerald, Noel J
Gomes-Solecki, Maria
Kintrup, Martin
Ledizet, Michel
Levin, Andrew E
Lewinski, Michael
Liotta, Lance A
Marques, Adriana
Mead, Paul S
Mongodin, Emmanuel F
Pillai, Segaran
Rao, Prasad
Robinson, William H
Roth, Kristian M
Schriefer, Martin E
Slezak, Thomas
Snyder, Jessica L
Steere, Allen C
Witkowski, Jan
Wong, Susan J
Branda, John A
author_sort Schutzer, Steven E
collection PubMed
description Borrelia burgdorferi was discovered to be the cause of Lyme disease in 1983, leading to seroassays. The 1994 serodiagnostic testing guidelines predated a full understanding of key B. burgdorferi antigens and have a number of shortcomings. These serologic tests cannot distinguish active infection, past infection, or reinfection. Reliable direct-detection methods for active B. burgdorferi infection have been lacking in the past but are needed and appear achievable. New approaches have effectively been applied to other emerging infections and show promise in direct detection of B. burgdorferi infections.
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spelling pubmed-63994342019-10-11 Direct Diagnostic Tests for Lyme Disease Schutzer, Steven E Body, Barbara A Boyle, Jeff Branson, Bernard M Dattwyler, Raymond J Fikrig, Erol Gerald, Noel J Gomes-Solecki, Maria Kintrup, Martin Ledizet, Michel Levin, Andrew E Lewinski, Michael Liotta, Lance A Marques, Adriana Mead, Paul S Mongodin, Emmanuel F Pillai, Segaran Rao, Prasad Robinson, William H Roth, Kristian M Schriefer, Martin E Slezak, Thomas Snyder, Jessica L Steere, Allen C Witkowski, Jan Wong, Susan J Branda, John A Clin Infect Dis Viewpoints Borrelia burgdorferi was discovered to be the cause of Lyme disease in 1983, leading to seroassays. The 1994 serodiagnostic testing guidelines predated a full understanding of key B. burgdorferi antigens and have a number of shortcomings. These serologic tests cannot distinguish active infection, past infection, or reinfection. Reliable direct-detection methods for active B. burgdorferi infection have been lacking in the past but are needed and appear achievable. New approaches have effectively been applied to other emerging infections and show promise in direct detection of B. burgdorferi infections. Oxford University Press 2019-03-15 2018-10-11 /pmc/articles/PMC6399434/ /pubmed/30307486 http://dx.doi.org/10.1093/cid/ciy614 Text en © The Author(s) 2018. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com. https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model) This article is made available via the PMC Open Access Subset for unrestricted re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the COVID-19 pandemic or until permissions are revoked in writing. Upon expiration of these permissions, PMC is granted a perpetual license to make this article available via PMC and Europe PMC, consistent with existing copyright protections.
spellingShingle Viewpoints
Schutzer, Steven E
Body, Barbara A
Boyle, Jeff
Branson, Bernard M
Dattwyler, Raymond J
Fikrig, Erol
Gerald, Noel J
Gomes-Solecki, Maria
Kintrup, Martin
Ledizet, Michel
Levin, Andrew E
Lewinski, Michael
Liotta, Lance A
Marques, Adriana
Mead, Paul S
Mongodin, Emmanuel F
Pillai, Segaran
Rao, Prasad
Robinson, William H
Roth, Kristian M
Schriefer, Martin E
Slezak, Thomas
Snyder, Jessica L
Steere, Allen C
Witkowski, Jan
Wong, Susan J
Branda, John A
Direct Diagnostic Tests for Lyme Disease
title Direct Diagnostic Tests for Lyme Disease
title_full Direct Diagnostic Tests for Lyme Disease
title_fullStr Direct Diagnostic Tests for Lyme Disease
title_full_unstemmed Direct Diagnostic Tests for Lyme Disease
title_short Direct Diagnostic Tests for Lyme Disease
title_sort direct diagnostic tests for lyme disease
topic Viewpoints
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399434/
https://www.ncbi.nlm.nih.gov/pubmed/30307486
http://dx.doi.org/10.1093/cid/ciy614
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