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Identification of amino acid residues in the ligand binding repeats of LDL receptor important for PCSK9 binding

Proprotein convertase subtilisin/kexin type 9 (PCSK9) promotes LDL receptor (LDLR) degradation, increasing plasma levels of LDL cholesterol and the risk of cardiovascular disease. We have previously shown that, in addition to the epidermal growth factor precursor homology repeat-A of LDLR, at least...

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Detalles Bibliográficos
Autores principales:	Deng, Shi-jun, Alabi, Adekunle, Gu, Hong-mei, Adijiang, Ayinuer, Qin, Shucun, Zhang, Da-wei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society for Biochemistry and Molecular Biology 2019
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399494/ https://www.ncbi.nlm.nih.gov/pubmed/30617148 http://dx.doi.org/10.1194/jlr.M089193

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