Cargando…

Therapeutic FGF19 promotes HDL biogenesis and transhepatic cholesterol efflux to prevent atherosclerosis

Fibroblast growth factor (FGF)19, an endocrine hormone produced in the gut, acts in the liver to control bile acid synthesis. NGM282, an engineered FGF19 analog, is currently in clinical development for treating nonalcoholic steatohepatitis. However, the molecular mechanisms that integrate FGF19 wit...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhou, Mei, Learned, R. Marc, Rossi, Stephen J., Tian, Hui, DePaoli, Alex M., Ling, Lei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society for Biochemistry and Molecular Biology 2019
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399511/ https://www.ncbi.nlm.nih.gov/pubmed/30679232 http://dx.doi.org/10.1194/jlr.M089961

Ejemplares similares

Engineered FGF19 eliminates bile acid toxicity and lipotoxicity leading to resolution of steatohepatitis and fibrosis in mice
por: Zhou, Mei, et al.
Publicado: (2017)

Lack of Correlation of Plasma HDL With Fecal Cholesterol and Plasma Cholesterol Efflux Capacity Suggests Importance of HDL Functionality in Attenuation of Atherosclerosis
por: Srivastava, Neelam, et al.
Publicado: (2018)

HDL cholesterol efflux capacity in rheumatoid arthritis patients: contributing factors and relationship with subclinical atherosclerosis
por: Tejera-Segura, Beatriz, et al.
Publicado: (2017)

ApoCIII enrichment in HDL impairs HDL-mediated cholesterol efflux capacity
por: Luo, Mengdie, et al.
Publicado: (2017)

Uremia alters HDL composition and cholesterol efflux capacity
por: Holzer, Michael, et al.
Publicado: (2012)

Nascent HDL (High-Density Lipoprotein) Discs Carry Cholesterol to HDL Spheres: Effects of HDL Particle Remodeling on Cholesterol Efflux
por: Navdaev, Alexei V., et al.
Publicado: (2020)

Engineered fibroblast growth factor 19 reduces liver injury and resolves sclerosing cholangitis in Mdr2‐deficient mice
por: Zhou, Mei, et al.
Publicado: (2016)

Testosterone replacement in hypogonadal men alters the HDL proteome but not HDL cholesterol efflux capacity
por: Rubinow, Katya B., et al.
Publicado: (2012)

Impaired HDL cholesterol efflux capacity in patients with non-alcoholic fatty liver disease is associated with subclinical atherosclerosis
por: Fadaei, Reza, et al.
Publicado: (2018)

Cholesterol efflux pathways, inflammation, and atherosclerosis
por: Groenen, Anouk G., et al.
Publicado: (2021)

The negative effect of ANGPTL8 on HDL-mediated cholesterol efflux capacity
por: Luo, Mengdie, et al.
Publicado: (2018)

9-cis β-Carotene Increased Cholesterol Efflux to HDL in Macrophages
por: Bechor, Sapir, et al.
Publicado: (2016)

Cholesterol Efflux Efficiency of Reconstituted HDL Is Affected by Nanoparticle Lipid Composition
por: Jebari-Benslaiman, Shifa, et al.
Publicado: (2020)

Lower than average HDL cholesterol efflux capacity in Lithuanian population
por: Kutkiene, Sandra, et al.
Publicado: (2019)

HDL cholesterol efflux capacity and lipid profile in patients with systemic sclerosis
por: Ferraz-Amaro, Iván, et al.
Publicado: (2021)

HDL Cholesterol Efflux and the Complement System Are Linked in Systemic Lupus Erythematosus
por: García-González, María, et al.
Publicado: (2023)

Scavenging dicarbonyls with 5′-O-pentyl-pyridoxamine increases HDL net cholesterol efflux capacity and attenuates atherosclerosis and insulin resistance
por: Huang, Jiansheng, et al.
Publicado: (2022)

Human paraoxonase 1 overexpression in mice stimulates HDL cholesterol efflux and reverse cholesterol transport
por: Ikhlef, Souade, et al.
Publicado: (2017)

Effects of pre-eclampsia on HDL-mediated cholesterol efflux capacity after pregnancy
por: Kockx, Maaike, et al.
Publicado: (2022)

HDL Improves Cholesterol and Glucose Homeostasis and Reduces Atherosclerosis in Diabetes-Associated Atherosclerosis
por: Di Bartolo, Belinda A., et al.
Publicado: (2021)

Enhanced HDL Functionality in Small HDL Species Produced Upon Remodeling of HDL by Reconstituted HDL, CSL112: Effects on Cholesterol Efflux, Anti-Inflammatory and Antioxidative Activity
por: Didichenko, Svetlana A., et al.
Publicado: (2016)

Impaired HDL2-mediated cholesterol efflux is associated with metabolic syndrome in families with early onset coronary heart disease and low HDL-cholesterol level
por: Paavola, Timo, et al.
Publicado: (2017)

In Vivo Inflammation Does Not Impair ABCA1-Mediated Cholesterol Efflux Capacity of HDL
por: Franssen, Remco, et al.
Publicado: (2012)

Extra Virgin Olive Oil Polyphenols Promote Cholesterol Efflux and Improve HDL Functionality
por: Berrougui, Hicham, et al.
Publicado: (2015)

A meta-analysis of HDL cholesterol efflux capacity and concentration in patients with rheumatoid arthritis
por: Xie, Binbin, et al.
Publicado: (2021)

The association between impairment of HDL cholesterol efflux capacity and atrial remodeling in atrial fibrillation
por: Minami-Takano, Asuka, et al.
Publicado: (2021)

Low HDL Cholesterol Efflux Capacity Indicates a Fatal Course of COVID-19
por: Stadler, Julia T., et al.
Publicado: (2022)

MicroRNA-320b Modulates Cholesterol Efflux and Atherosclerosis
por: Lu, Xiaomei, et al.
Publicado: (2022)

HDL Cholesterol Efflux and Serum Cholesterol Loading Capacity Alterations Associate to Macrophage Cholesterol Accumulation in FH Patients with Achilles Tendon Xanthoma
por: Adorni, Maria Pia, et al.
Publicado: (2022)

Roles of the Metabolic Syndrome, HDL Cholesterol, and Coronary Atherosclerosis in Subclinical Inflammation
por: Rein, Philipp, et al.
Publicado: (2010)

Triglyceride/HDL-Cholesterol Ratio as an Index of Intracranial Atherosclerosis in Nonstroke Individuals
por: Woo, Min-Hee, et al.
Publicado: (2021)

Impaired HDL cholesterol efflux in metabolic syndrome is unrelated to glucose tolerance status: the CODAM study
por: Annema, Wijtske, et al.
Publicado: (2016)

Effect of Selective Androgen Receptor Modulator on Cholesterol Efflux Capacity, Size, and Subspecies of HDL Particles
por: Guo, Wen, et al.
Publicado: (2022)

Lipid-Based Nutrient Supplementation Increases High-Density Lipoprotein (HDL) Cholesterol Efflux Capacity and Is Associated with Changes in the HDL Glycoproteome in Children
por: Hong, Brian V., et al.
Publicado: (2021)

HDL functionality in type 1 diabetes: enhancement of cholesterol efflux capacity in relationship with decreased HDL carbamylation after improvement of glycemic control
por: Denimal, Damien, et al.
Publicado: (2022)

Higher non-HDL-cholesterol to HDL-cholesterol ratio linked with increased nonalcoholic steatohepatitis
por: Wang, Dianhui, et al.
Publicado: (2018)

Carvedilol Ameliorates Experimental Atherosclerosis by Regulating Cholesterol Efflux and Exosome Functions
por: Chen, Sy-Jou, et al.
Publicado: (2019)

Decreased APOE-containing HDL subfractions and cholesterol efflux capacity of serum in mice lacking Pcsk9
por: Choi, Seungbum, et al.
Publicado: (2013)

The Association Between Reduction in Inflammation and Changes in Lipoprotein Levels and HDL Cholesterol Efflux Capacity in Rheumatoid Arthritis
por: Liao, Katherine P., et al.
Publicado: (2015)

Impact of Lifestyle Intervention on HDL-Induced eNOS Activation and Cholesterol Efflux Capacity in Obese Adolescent
por: Wesnigk, Jenny, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_jprfrbbb0m1hr0rtdp5orl0418