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Likelihood-Ratio-Test Methods for Drug Safety Signal Detection from Multiple Clinical Datasets
Pre- and postmarket drug safety evaluations usually include an integrated summary of results obtained using data from multiple studies related to a drug of interest. This paper proposes three approaches based on the likelihood ratio test (LRT), called the LRT methods, for drug safety signal detectio...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Hindawi
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399568/ https://www.ncbi.nlm.nih.gov/pubmed/30915153 http://dx.doi.org/10.1155/2019/1526290 |