Cargando…

The lysine‐specific methyltransferase KMT2C/MLL3 regulates DNA repair components in cancer

Genome‐wide studies in tumor cells have indicated that chromatin‐modifying proteins are commonly mutated in human cancers. The lysine‐specific methyltransferase 2C (KMT2C/MLL3) is a putative tumor suppressor in several epithelia and in myeloid cells. Here, we show that downregulation of KMT2C in bla...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rampias, Theodoros, Karagiannis, Dimitris, Avgeris, Margaritis, Polyzos, Alexander, Kokkalis, Antonis, Kanaki, Zoi, Kousidou, Evgenia, Tzetis, Maria, Kanavakis, Emmanouil, Stravodimos, Konstantinos, Manola, Kalliopi N, Pantelias, Gabriel E, Scorilas, Andreas, Klinakis, Apostolos
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2019
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399616/ https://www.ncbi.nlm.nih.gov/pubmed/30665945 http://dx.doi.org/10.15252/embr.201846821

Ejemplares similares

Structure, Activity and Function of the MLL2 (KMT2B) Protein Lysine Methyltransferase
por: Klonou, Alexia, et al.
Publicado: (2021)

tRNA-Derived Fragments (tRFs) in Bladder Cancer: Increased 5′-tRF-LysCTT Results in Disease Early Progression and Patients’ Poor Treatment Outcome
por: Papadimitriou, Maria-Alexandra, et al.
Publicado: (2020)

Loss of GAS5 tumour suppressor lncRNA: an independent molecular cancer biomarker for short-term relapse and progression in bladder cancer patients
por: Avgeris, Margaritis, et al.
Publicado: (2018)

The loss of the tumour-suppressor miR-145 results in the shorter disease-free survival of prostate cancer patients
por: Avgeris, M, et al.
Publicado: (2013)

Generation of Non-Small Cell Lung Cancer Patient-Derived Xenografts to Study Intratumor Heterogeneity
por: Kanaki, Zoi, et al.
Publicado: (2021)

MLL2/KMT2D and MLL3/KMT2C expression correlates with disease progression and response to imatinib mesylate in chronic myeloid leukemia
por: Rabello, Doralina do Amaral, et al.
Publicado: (2018)

Epigenetic regulation of MIR145 core promoter controls miR-143/145 cluster in bladder cancer progression and treatment outcome
por: Pilala, Katerina-Marina, et al.
Publicado: (2022)

Down-regulation of kallikrein-related peptidase 5 (KLK5) expression in breast cancer patients: a biomarker for the differential diagnosis of breast lesions
por: Avgeris, Margaritis, et al.
Publicado: (2011)

Evaluation of the Small Heat Shock Protein Family Members HSPB2 and HSPB3 in Bladder Cancer Prognosis and Progression
por: Gianniou, Despoina D., et al.
Publicado: (2023)

TP53 mutational landscape of metastatic head and neck cancer reveals patterns of mutation selection
por: Klinakis, Apostolos, et al.
Publicado: (2020)

Drug Repurposing for Targeting Acute Leukemia With KMT2A (MLL)—Gene Rearrangements
por: Tsakaneli, Alexia, et al.
Publicado: (2021)

Human MLL/KMT2A gene exhibits a second breakpoint cluster region for recurrent MLL–USP2 fusions
por: Meyer, Claus, et al.
Publicado: (2019)

Deregulated Expression of IL-37 in Patients with Bladder Urothelial Cancer: The Diagnostic Potential of the IL-37e Isoform
por: Papasavva, Maria, et al.
Publicado: (2023)

Dll1 Marks Cells of Origin of Ras-Induced Cancer in Mouse Squamous Epithelia
por: Vasilaki, Eleni, et al.
Publicado: (2018)

The Epigenetic Enzyme KMT2A/MLL1 Is a Driver of Coronavirus-associated Coagulopathy
por: Sharma, Sriganesh B., et al.
Publicado: (2022)

Outcomes of acute lymphoblastic leukemia with KMT2A (MLL) rearrangement: the MD Anderson experience
por: Richard-Carpentier, Guillaume, et al.
Publicado: (2021)

DNA fragility at the KMT2A/MLL locus: insights from old and new technologies
por: Cowell, Ian G., et al.
Publicado: (2023)

N-terminal domain mutations of the spike protein are structurally implicated in epitope recognition in emerging SARS-CoV-2 strains
por: Klinakis, Apostolos, et al.
Publicado: (2021)

The histone methyltransferase MLL1/KMT2A in monocytes drives coronavirus-associated coagulopathy and inflammation
por: Sharma, Sriganesh B., et al.
Publicado: (2023)

KMT2D/MLL2 inactivation is associated with recurrence in adult-type granulosa cell tumors of the ovary
por: Hillman, R. Tyler, et al.
Publicado: (2018)

Rare myeloid sarcoma with KMT2A (MLL)-ELL fusion presenting as a vaginal wall mass
por: Bao, Haiyan, et al.
Publicado: (2019)

KRT14 marks a subpopulation of bladder basal cells with pivotal role in regeneration and tumorigenesis
por: Papafotiou, George, et al.
Publicado: (2016)

Loss of Kmt2c in vivo leads to EMT, mitochondrial dysfunction and improved response to lapatinib in breast cancer
por: Simigdala, Nikiana, et al.
Publicado: (2023)

CHUK/IKK-α loss in lung epithelial cells enhances NSCLC growth associated with HIF up-regulation
por: Chavdoula, Evangelia, et al.
Publicado: (2019)

Three de novo variants in KMT2A (MLL) identified by whole exome sequencing in patients with Wiedemann–Steiner syndrome
por: Luo, Sukun, et al.
Publicado: (2021)

Editorial: Harnessing chemotherapy resistance and development of novel therapeutic strategies for acute leukemia with KMT2A (MLL)-gene rearrangements
por: Esposito, Maria Teresa, et al.
Publicado: (2022)

Tyrosine kinases in KMT2A/MLL-rearranged acute leukemias as potential therapeutic targets to overcome cancer drug resistance
por: Uckun, Fatih M., et al.
Publicado: (2022)

miR-125b predicts childhood acute lymphoblastic leukaemia poor response to BFM chemotherapy treatment
por: Piatopoulou, Despina, et al.
Publicado: (2017)

Interplay between Sulfur Assimilation and Biodesulfurization Activity in Rhodococcus qingshengii IGTS8: Insights into a Regulatory Role of the Reverse Transsulfuration Pathway
por: Martzoukou, Olga, et al.
Publicado: (2022)

HDAC Inhibitors: Dissecting Mechanisms of Action to Counter Tumor Heterogeneity
por: Karagiannis, Dimitris, et al.
Publicado: (2021)

Cancer Evolution in Precision Medicine Era
por: Karagiannis, Dimitris, et al.
Publicado: (2022)

KMT2C promoter methylation in plasma‐circulating tumor DNA is a prognostic biomarker in non‐small cell lung cancer
por: Mastoraki, Sofia, et al.
Publicado: (2020)

Mitigation of SARS-CoV2-Mediated Endothelial Injury via Suppression of the Epigenetic Enzyme KMT2A/MLL1 in Macrophages
por: Sharma, Sriganesh, et al.
Publicado: (2022)

Overexpression of the GR Riborepressor LncRNA GAS5 Results in Poor Treatment Response and Early Relapse in Childhood B-ALL
por: Xagorari, Marieta, et al.
Publicado: (2021)

Protein kinase Msk1 physically and functionally interacts with the KMT2A/MLL1 methyltransferase complex and contributes to the regulation of multiple target genes
por: Wiersma, Maaike, et al.
Publicado: (2016)

Resolving DNA Damage: Epigenetic Regulation of DNA Repair
por: Karakaidos, Panagiotis, et al.
Publicado: (2020)

Histone H1 variant-specific lysine methylation by G9a/KMT1C and Glp1/KMT1D
por: Weiss, Thomas, et al.
Publicado: (2010)

De Novo variants in the KMT2A (MLL) gene causing atypical Wiedemann-Steiner syndrome in two unrelated individuals identified by clinical exome sequencing
por: Strom, Samuel P, et al.
Publicado: (2014)

Magnetic nanoparticles coated with polyarabic acid demonstrate enhanced drug delivery and imaging properties for cancer theranostic applications
por: Patitsa, Maria, et al.
Publicado: (2017)

Blood-based analysis of type-2 diabetes mellitus susceptibility genes identifies specific transcript variants with deregulated expression and association with disease risk
por: Christodoulou, Maria-Ioanna, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_bgkin4i006snsmf564ugbb3flf