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Frontier molecular orbital effects control the hole-catalyzed racemization of atropisomeric biaryls
Atropisomeric biaryl systems are privileged architectures used in asymmetric synthesis and pharmaceutical structures. We report that by simply removing a single-electron, the resistance of biaryls towards racemization is reduced dramatically. Even though the steric properties are unaltered, biaryl o...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Royal Society of Chemistry
2018
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399675/ https://www.ncbi.nlm.nih.gov/pubmed/30931095 http://dx.doi.org/10.1039/c8sc05066j |