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Urine proteome changes associated with autonomic regulation of heart rate in cosmonauts

BACKGROUND: The strategy of adaptation of the human body in microgravity is largely associated with the plasticity of cardiovascular system regulatory mechanisms. During long-term space flights the changes in the stroke volume of the heart are observed, the heart rate decreases, the phase structure...

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Autores principales: Pastushkova, Lyudmila H., Rusanov, Vasily B., Goncharova, Anna G., Brzhozovskiy, Alexander G., Kononikhin, Alexey S., Chernikova, Anna G., Kashirina, Daria N., Nosovsky, Andrey M., Baevsky, Roman M., Nikolaev, Evgeny N., Larina, Irina M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399814/
https://www.ncbi.nlm.nih.gov/pubmed/30836973
http://dx.doi.org/10.1186/s12918-019-0688-9
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author Pastushkova, Lyudmila H.
Rusanov, Vasily B.
Goncharova, Anna G.
Brzhozovskiy, Alexander G.
Kononikhin, Alexey S.
Chernikova, Anna G.
Kashirina, Daria N.
Nosovsky, Andrey M.
Baevsky, Roman M.
Nikolaev, Evgeny N.
Larina, Irina M.
author_facet Pastushkova, Lyudmila H.
Rusanov, Vasily B.
Goncharova, Anna G.
Brzhozovskiy, Alexander G.
Kononikhin, Alexey S.
Chernikova, Anna G.
Kashirina, Daria N.
Nosovsky, Andrey M.
Baevsky, Roman M.
Nikolaev, Evgeny N.
Larina, Irina M.
author_sort Pastushkova, Lyudmila H.
collection PubMed
description BACKGROUND: The strategy of adaptation of the human body in microgravity is largely associated with the plasticity of cardiovascular system regulatory mechanisms. During long-term space flights the changes in the stroke volume of the heart are observed, the heart rate decreases, the phase structure of cardiac cycle is readjusted The purpose of this work was to clarify urine proteome changes associated with the initial condition of the heart rate autonomic regulation mechanisms in cosmonauts who have participated in long space missions. Urine proteome of each cosmonaut was analyzed before and after space flight, depending on the initial parameters characterizing the regulatory mechanisms of the cardiovascular system. RESULTS: The proteins cadherin-13, mucin-1, alpha-1 of collagen subunit type VI (COL6A1), hemisentin-1, semenogelin-2, SH3 domain-binding protein, transthyretin and serine proteases inhibitors realize a homeostatic role in individuals with different initial type of the cardiovascular system regulation. The role of significantly changed urine proteins in the cardiovascular homeostasis maintenance is associated with complex processes of atherogenesis, neoangiogenesis, activation of calcium channels, changes in cell adhesion and transmembrane properties, changes in extracellular matrix, participation in protection from oxidative stress and leveling the effects of hypoxia. Therefore, the concentrations of these proteins significantly differ between groups with dominant parasympathetic and sympathetic influences. CONCLUSION: The space flight induced urine proteome changes are significantly different in the groups identified by heart rate autonomic regulation peculiarities before space flight. All these proteins regulate the associated biological processes which affect the stiffness of the vascular wall, blood pressure level, the severity of atherosclerotic changes, the rate and degree of age-related involution of elastin and fibulin, age-related increase in collagen stiffness, genetically determined features of elastin fibers. The increased vascular rigidity (including the aorta) and of myocardium may be regarded as a universal response to various extreme factors. Significant differences in the semi-quantitative analysis of signal proteins between groups with different types of autonomic regulation are explained by a common goal: to ensure optimal adaptation regardless of age and of the genetically determined type of responses to the extreme environmental factors effects. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12918-019-0688-9) contains supplementary material, which is available to authorized users.
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spelling pubmed-63998142019-03-25 Urine proteome changes associated with autonomic regulation of heart rate in cosmonauts Pastushkova, Lyudmila H. Rusanov, Vasily B. Goncharova, Anna G. Brzhozovskiy, Alexander G. Kononikhin, Alexey S. Chernikova, Anna G. Kashirina, Daria N. Nosovsky, Andrey M. Baevsky, Roman M. Nikolaev, Evgeny N. Larina, Irina M. BMC Syst Biol Research BACKGROUND: The strategy of adaptation of the human body in microgravity is largely associated with the plasticity of cardiovascular system regulatory mechanisms. During long-term space flights the changes in the stroke volume of the heart are observed, the heart rate decreases, the phase structure of cardiac cycle is readjusted The purpose of this work was to clarify urine proteome changes associated with the initial condition of the heart rate autonomic regulation mechanisms in cosmonauts who have participated in long space missions. Urine proteome of each cosmonaut was analyzed before and after space flight, depending on the initial parameters characterizing the regulatory mechanisms of the cardiovascular system. RESULTS: The proteins cadherin-13, mucin-1, alpha-1 of collagen subunit type VI (COL6A1), hemisentin-1, semenogelin-2, SH3 domain-binding protein, transthyretin and serine proteases inhibitors realize a homeostatic role in individuals with different initial type of the cardiovascular system regulation. The role of significantly changed urine proteins in the cardiovascular homeostasis maintenance is associated with complex processes of atherogenesis, neoangiogenesis, activation of calcium channels, changes in cell adhesion and transmembrane properties, changes in extracellular matrix, participation in protection from oxidative stress and leveling the effects of hypoxia. Therefore, the concentrations of these proteins significantly differ between groups with dominant parasympathetic and sympathetic influences. CONCLUSION: The space flight induced urine proteome changes are significantly different in the groups identified by heart rate autonomic regulation peculiarities before space flight. All these proteins regulate the associated biological processes which affect the stiffness of the vascular wall, blood pressure level, the severity of atherosclerotic changes, the rate and degree of age-related involution of elastin and fibulin, age-related increase in collagen stiffness, genetically determined features of elastin fibers. The increased vascular rigidity (including the aorta) and of myocardium may be regarded as a universal response to various extreme factors. Significant differences in the semi-quantitative analysis of signal proteins between groups with different types of autonomic regulation are explained by a common goal: to ensure optimal adaptation regardless of age and of the genetically determined type of responses to the extreme environmental factors effects. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12918-019-0688-9) contains supplementary material, which is available to authorized users. BioMed Central 2019-03-05 /pmc/articles/PMC6399814/ /pubmed/30836973 http://dx.doi.org/10.1186/s12918-019-0688-9 Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Pastushkova, Lyudmila H.
Rusanov, Vasily B.
Goncharova, Anna G.
Brzhozovskiy, Alexander G.
Kononikhin, Alexey S.
Chernikova, Anna G.
Kashirina, Daria N.
Nosovsky, Andrey M.
Baevsky, Roman M.
Nikolaev, Evgeny N.
Larina, Irina M.
Urine proteome changes associated with autonomic regulation of heart rate in cosmonauts
title Urine proteome changes associated with autonomic regulation of heart rate in cosmonauts
title_full Urine proteome changes associated with autonomic regulation of heart rate in cosmonauts
title_fullStr Urine proteome changes associated with autonomic regulation of heart rate in cosmonauts
title_full_unstemmed Urine proteome changes associated with autonomic regulation of heart rate in cosmonauts
title_short Urine proteome changes associated with autonomic regulation of heart rate in cosmonauts
title_sort urine proteome changes associated with autonomic regulation of heart rate in cosmonauts
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399814/
https://www.ncbi.nlm.nih.gov/pubmed/30836973
http://dx.doi.org/10.1186/s12918-019-0688-9
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