Modeling to capture bystander-killing effect by released payload in target positive tumor cells

BACKGROUND: Antibody-drug conjugates (ADCs) are intended to bind to specific positive target antigens and eradicate only tumor cells from an intracellular released payload through the lysosomal protease. Payloads, such as MMAE, have the capacity to kill adjacent antigen-negative (Ag–) tumor cells, w...

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Detalles Bibliográficos
Autores principales: Byun, Jong Hyuk, Jung, Il Hyo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399851/
https://www.ncbi.nlm.nih.gov/pubmed/30832603
http://dx.doi.org/10.1186/s12885-019-5336-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399851/
https://www.ncbi.nlm.nih.gov/pubmed/30832603
http://dx.doi.org/10.1186/s12885-019-5336-7

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