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Modeling to capture bystander-killing effect by released payload in target positive tumor cells
BACKGROUND: Antibody-drug conjugates (ADCs) are intended to bind to specific positive target antigens and eradicate only tumor cells from an intracellular released payload through the lysosomal protease. Payloads, such as MMAE, have the capacity to kill adjacent antigen-negative (Ag–) tumor cells, w...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399851/ https://www.ncbi.nlm.nih.gov/pubmed/30832603 http://dx.doi.org/10.1186/s12885-019-5336-7 |