Isocytosine deaminase Vcz as a novel tool for the prodrug cancer therapy

BACKGROUND: The cytosine deaminase (CD)/5-fluorocytosine (5-FC) system is among the best explored enzyme/prodrug systems in the field of the suicide gene therapy. Recently, by the screening of the environmental metagenomic libraries we identified a novel isocytosine deaminase (ICD), termed Vcz, whic...

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Detalles Bibliográficos
Autores principales: Kazlauskas, Arunas, Darinskas, Adas, Meškys, Rolandas, Tamašauskas, Arimantas, Urbonavičius, Jaunius
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399854/
https://www.ncbi.nlm.nih.gov/pubmed/30832616
http://dx.doi.org/10.1186/s12885-019-5409-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399854/
https://www.ncbi.nlm.nih.gov/pubmed/30832616
http://dx.doi.org/10.1186/s12885-019-5409-7

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