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Human SPG11 cerebral organoids reveal cortical neurogenesis impairment

Spastic paraplegia gene 11(SPG11)-linked hereditary spastic paraplegia is a complex monogenic neurodegenerative disease that in addition to spastic paraplegia is characterized by childhood onset cognitive impairment, thin corpus callosum and enlarged ventricles. We have previously shown impaired pro...

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Detalles Bibliográficos
Autores principales:	Pérez-Brangulí, Francesc, Buchsbaum, Isabel Y, Pozner, Tatyana, Regensburger, Martin, Fan, Wenqiang, Schray, Annika, Börstler, Tom, Mishra, Himanshu, Gräf, Daniela, Kohl, Zacharias, Winkler, Jürgen, Berninger, Benedikt, Cappello, Silvia, Winner, Beate
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2019
Materias:	General Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6400051/ https://www.ncbi.nlm.nih.gov/pubmed/30476097 http://dx.doi.org/10.1093/hmg/ddy397

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