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A Subset of CCL25-Induced Gut-Homing T Cells Affects Intestinal Immunity to Infection and Cancer

Protective immunity relies upon differentiation of T cells into the appropriate subtype required to clear infections and efficient effector T cell localization to antigen-rich tissue. Recent studies have highlighted the role played by subpopulations of tissue-resident memory (T(RM)) T lymphocytes in...

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Autores principales: Fu, Hongmei, Jangani, Maryam, Parmar, Aleesha, Wang, Guosu, Coe, David, Spear, Sarah, Sandrock, Inga, Capasso, Melania, Coles, Mark, Cornish, Georgina, Helmby, Helena, Marelli-Berg, Federica M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6400137/
https://www.ncbi.nlm.nih.gov/pubmed/30863398
http://dx.doi.org/10.3389/fimmu.2019.00271
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author Fu, Hongmei
Jangani, Maryam
Parmar, Aleesha
Wang, Guosu
Coe, David
Spear, Sarah
Sandrock, Inga
Capasso, Melania
Coles, Mark
Cornish, Georgina
Helmby, Helena
Marelli-Berg, Federica M.
author_facet Fu, Hongmei
Jangani, Maryam
Parmar, Aleesha
Wang, Guosu
Coe, David
Spear, Sarah
Sandrock, Inga
Capasso, Melania
Coles, Mark
Cornish, Georgina
Helmby, Helena
Marelli-Berg, Federica M.
author_sort Fu, Hongmei
collection PubMed
description Protective immunity relies upon differentiation of T cells into the appropriate subtype required to clear infections and efficient effector T cell localization to antigen-rich tissue. Recent studies have highlighted the role played by subpopulations of tissue-resident memory (T(RM)) T lymphocytes in the protection from invading pathogens. The intestinal mucosa and associated lymphoid tissue are densely populated by a variety of resident lymphocyte populations, including αβ and γδ CD8(+) intraepithelial T lymphocytes (IELs) and CD4(+) T cells. While the development of intestinal γδ CD8(+) IELs has been extensively investigated, the origin and function of intestinal CD4(+) T cells have not been clarified. We report that CCR9 signals delivered during naïve T cell priming promote the differentiation of a population of [Formula: see text] IFN-γ-producing memory CD4(+) T cells, which displays a T(RM) molecular signature, preferentially localizes to the gastrointestinal (GI) tract and associated lymphoid tissue and cannot be mobilized by remote antigenic challenge. We further show that this population shapes the immune microenvironment of GI tissue, thus affecting effector immunity in infection and cancer.
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spelling pubmed-64001372019-03-12 A Subset of CCL25-Induced Gut-Homing T Cells Affects Intestinal Immunity to Infection and Cancer Fu, Hongmei Jangani, Maryam Parmar, Aleesha Wang, Guosu Coe, David Spear, Sarah Sandrock, Inga Capasso, Melania Coles, Mark Cornish, Georgina Helmby, Helena Marelli-Berg, Federica M. Front Immunol Immunology Protective immunity relies upon differentiation of T cells into the appropriate subtype required to clear infections and efficient effector T cell localization to antigen-rich tissue. Recent studies have highlighted the role played by subpopulations of tissue-resident memory (T(RM)) T lymphocytes in the protection from invading pathogens. The intestinal mucosa and associated lymphoid tissue are densely populated by a variety of resident lymphocyte populations, including αβ and γδ CD8(+) intraepithelial T lymphocytes (IELs) and CD4(+) T cells. While the development of intestinal γδ CD8(+) IELs has been extensively investigated, the origin and function of intestinal CD4(+) T cells have not been clarified. We report that CCR9 signals delivered during naïve T cell priming promote the differentiation of a population of [Formula: see text] IFN-γ-producing memory CD4(+) T cells, which displays a T(RM) molecular signature, preferentially localizes to the gastrointestinal (GI) tract and associated lymphoid tissue and cannot be mobilized by remote antigenic challenge. We further show that this population shapes the immune microenvironment of GI tissue, thus affecting effector immunity in infection and cancer. Frontiers Media S.A. 2019-02-25 /pmc/articles/PMC6400137/ /pubmed/30863398 http://dx.doi.org/10.3389/fimmu.2019.00271 Text en Copyright © 2019 Fu, Jangani, Parmar, Wang, Coe, Spear, Sandrock, Capasso, Coles, Cornish, Helmby and Marelli-Berg. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Fu, Hongmei
Jangani, Maryam
Parmar, Aleesha
Wang, Guosu
Coe, David
Spear, Sarah
Sandrock, Inga
Capasso, Melania
Coles, Mark
Cornish, Georgina
Helmby, Helena
Marelli-Berg, Federica M.
A Subset of CCL25-Induced Gut-Homing T Cells Affects Intestinal Immunity to Infection and Cancer
title A Subset of CCL25-Induced Gut-Homing T Cells Affects Intestinal Immunity to Infection and Cancer
title_full A Subset of CCL25-Induced Gut-Homing T Cells Affects Intestinal Immunity to Infection and Cancer
title_fullStr A Subset of CCL25-Induced Gut-Homing T Cells Affects Intestinal Immunity to Infection and Cancer
title_full_unstemmed A Subset of CCL25-Induced Gut-Homing T Cells Affects Intestinal Immunity to Infection and Cancer
title_short A Subset of CCL25-Induced Gut-Homing T Cells Affects Intestinal Immunity to Infection and Cancer
title_sort subset of ccl25-induced gut-homing t cells affects intestinal immunity to infection and cancer
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6400137/
https://www.ncbi.nlm.nih.gov/pubmed/30863398
http://dx.doi.org/10.3389/fimmu.2019.00271
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