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A Subset of CCL25-Induced Gut-Homing T Cells Affects Intestinal Immunity to Infection and Cancer
Protective immunity relies upon differentiation of T cells into the appropriate subtype required to clear infections and efficient effector T cell localization to antigen-rich tissue. Recent studies have highlighted the role played by subpopulations of tissue-resident memory (T(RM)) T lymphocytes in...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6400137/ https://www.ncbi.nlm.nih.gov/pubmed/30863398 http://dx.doi.org/10.3389/fimmu.2019.00271 |
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author | Fu, Hongmei Jangani, Maryam Parmar, Aleesha Wang, Guosu Coe, David Spear, Sarah Sandrock, Inga Capasso, Melania Coles, Mark Cornish, Georgina Helmby, Helena Marelli-Berg, Federica M. |
author_facet | Fu, Hongmei Jangani, Maryam Parmar, Aleesha Wang, Guosu Coe, David Spear, Sarah Sandrock, Inga Capasso, Melania Coles, Mark Cornish, Georgina Helmby, Helena Marelli-Berg, Federica M. |
author_sort | Fu, Hongmei |
collection | PubMed |
description | Protective immunity relies upon differentiation of T cells into the appropriate subtype required to clear infections and efficient effector T cell localization to antigen-rich tissue. Recent studies have highlighted the role played by subpopulations of tissue-resident memory (T(RM)) T lymphocytes in the protection from invading pathogens. The intestinal mucosa and associated lymphoid tissue are densely populated by a variety of resident lymphocyte populations, including αβ and γδ CD8(+) intraepithelial T lymphocytes (IELs) and CD4(+) T cells. While the development of intestinal γδ CD8(+) IELs has been extensively investigated, the origin and function of intestinal CD4(+) T cells have not been clarified. We report that CCR9 signals delivered during naïve T cell priming promote the differentiation of a population of [Formula: see text] IFN-γ-producing memory CD4(+) T cells, which displays a T(RM) molecular signature, preferentially localizes to the gastrointestinal (GI) tract and associated lymphoid tissue and cannot be mobilized by remote antigenic challenge. We further show that this population shapes the immune microenvironment of GI tissue, thus affecting effector immunity in infection and cancer. |
format | Online Article Text |
id | pubmed-6400137 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-64001372019-03-12 A Subset of CCL25-Induced Gut-Homing T Cells Affects Intestinal Immunity to Infection and Cancer Fu, Hongmei Jangani, Maryam Parmar, Aleesha Wang, Guosu Coe, David Spear, Sarah Sandrock, Inga Capasso, Melania Coles, Mark Cornish, Georgina Helmby, Helena Marelli-Berg, Federica M. Front Immunol Immunology Protective immunity relies upon differentiation of T cells into the appropriate subtype required to clear infections and efficient effector T cell localization to antigen-rich tissue. Recent studies have highlighted the role played by subpopulations of tissue-resident memory (T(RM)) T lymphocytes in the protection from invading pathogens. The intestinal mucosa and associated lymphoid tissue are densely populated by a variety of resident lymphocyte populations, including αβ and γδ CD8(+) intraepithelial T lymphocytes (IELs) and CD4(+) T cells. While the development of intestinal γδ CD8(+) IELs has been extensively investigated, the origin and function of intestinal CD4(+) T cells have not been clarified. We report that CCR9 signals delivered during naïve T cell priming promote the differentiation of a population of [Formula: see text] IFN-γ-producing memory CD4(+) T cells, which displays a T(RM) molecular signature, preferentially localizes to the gastrointestinal (GI) tract and associated lymphoid tissue and cannot be mobilized by remote antigenic challenge. We further show that this population shapes the immune microenvironment of GI tissue, thus affecting effector immunity in infection and cancer. Frontiers Media S.A. 2019-02-25 /pmc/articles/PMC6400137/ /pubmed/30863398 http://dx.doi.org/10.3389/fimmu.2019.00271 Text en Copyright © 2019 Fu, Jangani, Parmar, Wang, Coe, Spear, Sandrock, Capasso, Coles, Cornish, Helmby and Marelli-Berg. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Fu, Hongmei Jangani, Maryam Parmar, Aleesha Wang, Guosu Coe, David Spear, Sarah Sandrock, Inga Capasso, Melania Coles, Mark Cornish, Georgina Helmby, Helena Marelli-Berg, Federica M. A Subset of CCL25-Induced Gut-Homing T Cells Affects Intestinal Immunity to Infection and Cancer |
title | A Subset of CCL25-Induced Gut-Homing T Cells Affects Intestinal Immunity to Infection and Cancer |
title_full | A Subset of CCL25-Induced Gut-Homing T Cells Affects Intestinal Immunity to Infection and Cancer |
title_fullStr | A Subset of CCL25-Induced Gut-Homing T Cells Affects Intestinal Immunity to Infection and Cancer |
title_full_unstemmed | A Subset of CCL25-Induced Gut-Homing T Cells Affects Intestinal Immunity to Infection and Cancer |
title_short | A Subset of CCL25-Induced Gut-Homing T Cells Affects Intestinal Immunity to Infection and Cancer |
title_sort | subset of ccl25-induced gut-homing t cells affects intestinal immunity to infection and cancer |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6400137/ https://www.ncbi.nlm.nih.gov/pubmed/30863398 http://dx.doi.org/10.3389/fimmu.2019.00271 |
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