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Vitamin D(3) supplementation improves testicular function in diabetic rats through peroxisome proliferator‐activated receptor‐γ/transforming growth factor‐beta 1/nuclear factor‐kappa B
AIMS/INTRODUCTION: Vitamin D(3) deficiency can lead to male hypogonadism in diabetes mellitus, but the target organs and the mechanism driving the disorder are unclear. This experiment was designed to study the relationship between vitamin D(3) deficiency and hypogonadism in diabetes mellitus. MATER...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6400168/ https://www.ncbi.nlm.nih.gov/pubmed/29953732 http://dx.doi.org/10.1111/jdi.12886 |
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author | Liu, Yang He, Yanyan Wang, Qingzhu Guo, Feng Huang, Fengjuan Ji, Linlin An, Tingting Qin, Guijun |
author_facet | Liu, Yang He, Yanyan Wang, Qingzhu Guo, Feng Huang, Fengjuan Ji, Linlin An, Tingting Qin, Guijun |
author_sort | Liu, Yang |
collection | PubMed |
description | AIMS/INTRODUCTION: Vitamin D(3) deficiency can lead to male hypogonadism in diabetes mellitus, but the target organs and the mechanism driving the disorder are unclear. This experiment was designed to study the relationship between vitamin D(3) deficiency and hypogonadism in diabetes mellitus. MATERIALS AND METHODS: Rats with streptozotocin‐induced diabetes were randomly divided into four groups and treated with different doses of vitamin D(3): blank (no vitamin D(3)), low (0.025 μg/kg/day), high (0.1 μg/kg/day), high (0.1 μg/kg/day) and with bisphenol A diglycidyl ether (peroxisome proliferator‐activated receptor gamma inhibitor 30 mg/kg/day). They were compared with wild‐type rats. RESULTS: After 12 weeks, the vitamin D(3) supplements had partially restored testicular pathological changes, as shown by reduced testicular fibrosis related to downregulation transforming growth factor beta 1 and apoptosis related to downregulation of nuclear factor kappa B, but not the pituitary gland. The expression of peroxisome proliferator‐activated receptor gamma, which can inhibit transforming growth factor beta 1 and nuclear factor kappa B, was significantly increased after treatment with vitamin D(3). CONCLUSIONS: These results suggest that treatment with vitamin D(3) can improve testicular function in diabetic rats through the peroxisome proliferator‐activated receptor gamma/transforming growth factor beta 1/nuclear factor kappa B signaling pathway. |
format | Online Article Text |
id | pubmed-6400168 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-64001682019-03-14 Vitamin D(3) supplementation improves testicular function in diabetic rats through peroxisome proliferator‐activated receptor‐γ/transforming growth factor‐beta 1/nuclear factor‐kappa B Liu, Yang He, Yanyan Wang, Qingzhu Guo, Feng Huang, Fengjuan Ji, Linlin An, Tingting Qin, Guijun J Diabetes Investig Articles AIMS/INTRODUCTION: Vitamin D(3) deficiency can lead to male hypogonadism in diabetes mellitus, but the target organs and the mechanism driving the disorder are unclear. This experiment was designed to study the relationship between vitamin D(3) deficiency and hypogonadism in diabetes mellitus. MATERIALS AND METHODS: Rats with streptozotocin‐induced diabetes were randomly divided into four groups and treated with different doses of vitamin D(3): blank (no vitamin D(3)), low (0.025 μg/kg/day), high (0.1 μg/kg/day), high (0.1 μg/kg/day) and with bisphenol A diglycidyl ether (peroxisome proliferator‐activated receptor gamma inhibitor 30 mg/kg/day). They were compared with wild‐type rats. RESULTS: After 12 weeks, the vitamin D(3) supplements had partially restored testicular pathological changes, as shown by reduced testicular fibrosis related to downregulation transforming growth factor beta 1 and apoptosis related to downregulation of nuclear factor kappa B, but not the pituitary gland. The expression of peroxisome proliferator‐activated receptor gamma, which can inhibit transforming growth factor beta 1 and nuclear factor kappa B, was significantly increased after treatment with vitamin D(3). CONCLUSIONS: These results suggest that treatment with vitamin D(3) can improve testicular function in diabetic rats through the peroxisome proliferator‐activated receptor gamma/transforming growth factor beta 1/nuclear factor kappa B signaling pathway. John Wiley and Sons Inc. 2018-08-06 2019-03 /pmc/articles/PMC6400168/ /pubmed/29953732 http://dx.doi.org/10.1111/jdi.12886 Text en © 2018 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Articles Liu, Yang He, Yanyan Wang, Qingzhu Guo, Feng Huang, Fengjuan Ji, Linlin An, Tingting Qin, Guijun Vitamin D(3) supplementation improves testicular function in diabetic rats through peroxisome proliferator‐activated receptor‐γ/transforming growth factor‐beta 1/nuclear factor‐kappa B |
title | Vitamin D(3) supplementation improves testicular function in diabetic rats through peroxisome proliferator‐activated receptor‐γ/transforming growth factor‐beta 1/nuclear factor‐kappa B |
title_full | Vitamin D(3) supplementation improves testicular function in diabetic rats through peroxisome proliferator‐activated receptor‐γ/transforming growth factor‐beta 1/nuclear factor‐kappa B |
title_fullStr | Vitamin D(3) supplementation improves testicular function in diabetic rats through peroxisome proliferator‐activated receptor‐γ/transforming growth factor‐beta 1/nuclear factor‐kappa B |
title_full_unstemmed | Vitamin D(3) supplementation improves testicular function in diabetic rats through peroxisome proliferator‐activated receptor‐γ/transforming growth factor‐beta 1/nuclear factor‐kappa B |
title_short | Vitamin D(3) supplementation improves testicular function in diabetic rats through peroxisome proliferator‐activated receptor‐γ/transforming growth factor‐beta 1/nuclear factor‐kappa B |
title_sort | vitamin d(3) supplementation improves testicular function in diabetic rats through peroxisome proliferator‐activated receptor‐γ/transforming growth factor‐beta 1/nuclear factor‐kappa b |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6400168/ https://www.ncbi.nlm.nih.gov/pubmed/29953732 http://dx.doi.org/10.1111/jdi.12886 |
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