Structure of mammalian plasma fetuin-B and its mechanism of selective metallopeptidase inhibition

Mammalian fetuin-A and fetuin-B are abundant serum proteins with pleiotropic functions. Fetuin-B is a highly selective and potent inhibitor of metallo­peptidases (MPs) of the astacin family, which includes ovastacin in mammals. By inhibiting ovastacin, fetuin-B is essential for female fertility. The...

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Detalles Bibliográficos
Autores principales: Cuppari, Anna, Körschgen, Hagen, Fahrenkamp, Dirk, Schmitz, Carlo, Guevara, Tibisay, Karmilin, Konstantin, Kuske, Michael, Olf, Mario, Dietzel, Eileen, Yiallouros, Irene, de Sanctis, Daniele, Goulas, Theodoros, Weiskirchen, Ralf, Jahnen-Dechent, Willi, Floehr, Julia, Stoecker, Walter, Jovine, Luca, Gomis-Rüth, F. Xavier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2019
Materias:
Research Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6400186/
https://www.ncbi.nlm.nih.gov/pubmed/30867929
http://dx.doi.org/10.1107/S2052252519001568

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