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Downregulation of peroxisome proliferator‐activated receptor gamma in the placenta correlates to hyperglycemia in offspring at young adulthood after exposure to gestational diabetes mellitus
AIMS/INTRODUCTION: Children who are exposed to gestational diabetes mellitus (GDM) in utero are at high risk of developing related illnesses, such as type 2 diabetes mellitus in young adulthood, but the underlying mechanism and related predictive biomarkers are not known. MATERIALS AND METHODS: The...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6400209/ https://www.ncbi.nlm.nih.gov/pubmed/30187673 http://dx.doi.org/10.1111/jdi.12928 |
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author | Zhao, Qihong Yang, Dong Gao, Lei Zhao, Mingqiu He, Xiujie Zhu, Meng Tian, Chaoqing Liu, Gang Li, Li Hu, Chuanlai |
author_facet | Zhao, Qihong Yang, Dong Gao, Lei Zhao, Mingqiu He, Xiujie Zhu, Meng Tian, Chaoqing Liu, Gang Li, Li Hu, Chuanlai |
author_sort | Zhao, Qihong |
collection | PubMed |
description | AIMS/INTRODUCTION: Children who are exposed to gestational diabetes mellitus (GDM) in utero are at high risk of developing related illnesses, such as type 2 diabetes mellitus in young adulthood, but the underlying mechanism and related predictive biomarkers are not known. MATERIALS AND METHODS: The present study identified the related biomarkers of hyperglycemia in young adults from the relationship between fetal blood glucose and placental lipid transporters at messenger ribonucleic acid (mRNA) and protein expression levels. We recruited patients from a prospective cohort, and determined the mRNA and protein levels of placental fatty acid transporters. Diet‐induced mouse models of GDM were established, and the mRNA and protein levels of the same transporters in placentas were validated. RESULTS: Only the mRNA levels of peroxisome proliferator‐activated receptor gamma correlated with the levels of neonatal blood glucose in GDM patients using linear regression and Spearman's correlation analyses (r = 0.774, P = 0.001). The mRNA levels of peroxisome proliferator‐activated receptor gamma, matrix metalloproteinase‐2 and fatty acid transport protein‐6 correlated with blood glucose levels in mouse offspring (r = 0.82, P = 0.001, r = 0.737, P = 0.006 and r = −0.891, P = 0.001, respectively) at young adulthood using the same analyses. Notably, we observed significantly higher blood glucose levels in GDM offspring at 12 weeks‐of‐age compared with the control and rosiglitazone‐supplemented groups (P < 0.05). CONCLUSIONS: The downregulation of peroxisome proliferator‐activated receptor gamma in the placenta might predict hyperglycemia in offspring at young adulthood. |
format | Online Article Text |
id | pubmed-6400209 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-64002092019-03-14 Downregulation of peroxisome proliferator‐activated receptor gamma in the placenta correlates to hyperglycemia in offspring at young adulthood after exposure to gestational diabetes mellitus Zhao, Qihong Yang, Dong Gao, Lei Zhao, Mingqiu He, Xiujie Zhu, Meng Tian, Chaoqing Liu, Gang Li, Li Hu, Chuanlai J Diabetes Investig Articles AIMS/INTRODUCTION: Children who are exposed to gestational diabetes mellitus (GDM) in utero are at high risk of developing related illnesses, such as type 2 diabetes mellitus in young adulthood, but the underlying mechanism and related predictive biomarkers are not known. MATERIALS AND METHODS: The present study identified the related biomarkers of hyperglycemia in young adults from the relationship between fetal blood glucose and placental lipid transporters at messenger ribonucleic acid (mRNA) and protein expression levels. We recruited patients from a prospective cohort, and determined the mRNA and protein levels of placental fatty acid transporters. Diet‐induced mouse models of GDM were established, and the mRNA and protein levels of the same transporters in placentas were validated. RESULTS: Only the mRNA levels of peroxisome proliferator‐activated receptor gamma correlated with the levels of neonatal blood glucose in GDM patients using linear regression and Spearman's correlation analyses (r = 0.774, P = 0.001). The mRNA levels of peroxisome proliferator‐activated receptor gamma, matrix metalloproteinase‐2 and fatty acid transport protein‐6 correlated with blood glucose levels in mouse offspring (r = 0.82, P = 0.001, r = 0.737, P = 0.006 and r = −0.891, P = 0.001, respectively) at young adulthood using the same analyses. Notably, we observed significantly higher blood glucose levels in GDM offspring at 12 weeks‐of‐age compared with the control and rosiglitazone‐supplemented groups (P < 0.05). CONCLUSIONS: The downregulation of peroxisome proliferator‐activated receptor gamma in the placenta might predict hyperglycemia in offspring at young adulthood. John Wiley and Sons Inc. 2018-10-19 2019-03 /pmc/articles/PMC6400209/ /pubmed/30187673 http://dx.doi.org/10.1111/jdi.12928 Text en © 2018 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Articles Zhao, Qihong Yang, Dong Gao, Lei Zhao, Mingqiu He, Xiujie Zhu, Meng Tian, Chaoqing Liu, Gang Li, Li Hu, Chuanlai Downregulation of peroxisome proliferator‐activated receptor gamma in the placenta correlates to hyperglycemia in offspring at young adulthood after exposure to gestational diabetes mellitus |
title | Downregulation of peroxisome proliferator‐activated receptor gamma in the placenta correlates to hyperglycemia in offspring at young adulthood after exposure to gestational diabetes mellitus |
title_full | Downregulation of peroxisome proliferator‐activated receptor gamma in the placenta correlates to hyperglycemia in offspring at young adulthood after exposure to gestational diabetes mellitus |
title_fullStr | Downregulation of peroxisome proliferator‐activated receptor gamma in the placenta correlates to hyperglycemia in offspring at young adulthood after exposure to gestational diabetes mellitus |
title_full_unstemmed | Downregulation of peroxisome proliferator‐activated receptor gamma in the placenta correlates to hyperglycemia in offspring at young adulthood after exposure to gestational diabetes mellitus |
title_short | Downregulation of peroxisome proliferator‐activated receptor gamma in the placenta correlates to hyperglycemia in offspring at young adulthood after exposure to gestational diabetes mellitus |
title_sort | downregulation of peroxisome proliferator‐activated receptor gamma in the placenta correlates to hyperglycemia in offspring at young adulthood after exposure to gestational diabetes mellitus |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6400209/ https://www.ncbi.nlm.nih.gov/pubmed/30187673 http://dx.doi.org/10.1111/jdi.12928 |
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