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Downregulation of peroxisome proliferator‐activated receptor gamma in the placenta correlates to hyperglycemia in offspring at young adulthood after exposure to gestational diabetes mellitus

AIMS/INTRODUCTION: Children who are exposed to gestational diabetes mellitus (GDM) in utero are at high risk of developing related illnesses, such as type 2 diabetes mellitus in young adulthood, but the underlying mechanism and related predictive biomarkers are not known. MATERIALS AND METHODS: The...

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Autores principales: Zhao, Qihong, Yang, Dong, Gao, Lei, Zhao, Mingqiu, He, Xiujie, Zhu, Meng, Tian, Chaoqing, Liu, Gang, Li, Li, Hu, Chuanlai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6400209/
https://www.ncbi.nlm.nih.gov/pubmed/30187673
http://dx.doi.org/10.1111/jdi.12928
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author Zhao, Qihong
Yang, Dong
Gao, Lei
Zhao, Mingqiu
He, Xiujie
Zhu, Meng
Tian, Chaoqing
Liu, Gang
Li, Li
Hu, Chuanlai
author_facet Zhao, Qihong
Yang, Dong
Gao, Lei
Zhao, Mingqiu
He, Xiujie
Zhu, Meng
Tian, Chaoqing
Liu, Gang
Li, Li
Hu, Chuanlai
author_sort Zhao, Qihong
collection PubMed
description AIMS/INTRODUCTION: Children who are exposed to gestational diabetes mellitus (GDM) in utero are at high risk of developing related illnesses, such as type 2 diabetes mellitus in young adulthood, but the underlying mechanism and related predictive biomarkers are not known. MATERIALS AND METHODS: The present study identified the related biomarkers of hyperglycemia in young adults from the relationship between fetal blood glucose and placental lipid transporters at messenger ribonucleic acid (mRNA) and protein expression levels. We recruited patients from a prospective cohort, and determined the mRNA and protein levels of placental fatty acid transporters. Diet‐induced mouse models of GDM were established, and the mRNA and protein levels of the same transporters in placentas were validated. RESULTS: Only the mRNA levels of peroxisome proliferator‐activated receptor gamma correlated with the levels of neonatal blood glucose in GDM patients using linear regression and Spearman's correlation analyses (r = 0.774, P = 0.001). The mRNA levels of peroxisome proliferator‐activated receptor gamma, matrix metalloproteinase‐2 and fatty acid transport protein‐6 correlated with blood glucose levels in mouse offspring (r = 0.82, P = 0.001, r = 0.737, P = 0.006 and r = −0.891, P = 0.001, respectively) at young adulthood using the same analyses. Notably, we observed significantly higher blood glucose levels in GDM offspring at 12 weeks‐of‐age compared with the control and rosiglitazone‐supplemented groups (P < 0.05). CONCLUSIONS: The downregulation of peroxisome proliferator‐activated receptor gamma in the placenta might predict hyperglycemia in offspring at young adulthood.
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spelling pubmed-64002092019-03-14 Downregulation of peroxisome proliferator‐activated receptor gamma in the placenta correlates to hyperglycemia in offspring at young adulthood after exposure to gestational diabetes mellitus Zhao, Qihong Yang, Dong Gao, Lei Zhao, Mingqiu He, Xiujie Zhu, Meng Tian, Chaoqing Liu, Gang Li, Li Hu, Chuanlai J Diabetes Investig Articles AIMS/INTRODUCTION: Children who are exposed to gestational diabetes mellitus (GDM) in utero are at high risk of developing related illnesses, such as type 2 diabetes mellitus in young adulthood, but the underlying mechanism and related predictive biomarkers are not known. MATERIALS AND METHODS: The present study identified the related biomarkers of hyperglycemia in young adults from the relationship between fetal blood glucose and placental lipid transporters at messenger ribonucleic acid (mRNA) and protein expression levels. We recruited patients from a prospective cohort, and determined the mRNA and protein levels of placental fatty acid transporters. Diet‐induced mouse models of GDM were established, and the mRNA and protein levels of the same transporters in placentas were validated. RESULTS: Only the mRNA levels of peroxisome proliferator‐activated receptor gamma correlated with the levels of neonatal blood glucose in GDM patients using linear regression and Spearman's correlation analyses (r = 0.774, P = 0.001). The mRNA levels of peroxisome proliferator‐activated receptor gamma, matrix metalloproteinase‐2 and fatty acid transport protein‐6 correlated with blood glucose levels in mouse offspring (r = 0.82, P = 0.001, r = 0.737, P = 0.006 and r = −0.891, P = 0.001, respectively) at young adulthood using the same analyses. Notably, we observed significantly higher blood glucose levels in GDM offspring at 12 weeks‐of‐age compared with the control and rosiglitazone‐supplemented groups (P < 0.05). CONCLUSIONS: The downregulation of peroxisome proliferator‐activated receptor gamma in the placenta might predict hyperglycemia in offspring at young adulthood. John Wiley and Sons Inc. 2018-10-19 2019-03 /pmc/articles/PMC6400209/ /pubmed/30187673 http://dx.doi.org/10.1111/jdi.12928 Text en © 2018 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Articles
Zhao, Qihong
Yang, Dong
Gao, Lei
Zhao, Mingqiu
He, Xiujie
Zhu, Meng
Tian, Chaoqing
Liu, Gang
Li, Li
Hu, Chuanlai
Downregulation of peroxisome proliferator‐activated receptor gamma in the placenta correlates to hyperglycemia in offspring at young adulthood after exposure to gestational diabetes mellitus
title Downregulation of peroxisome proliferator‐activated receptor gamma in the placenta correlates to hyperglycemia in offspring at young adulthood after exposure to gestational diabetes mellitus
title_full Downregulation of peroxisome proliferator‐activated receptor gamma in the placenta correlates to hyperglycemia in offspring at young adulthood after exposure to gestational diabetes mellitus
title_fullStr Downregulation of peroxisome proliferator‐activated receptor gamma in the placenta correlates to hyperglycemia in offspring at young adulthood after exposure to gestational diabetes mellitus
title_full_unstemmed Downregulation of peroxisome proliferator‐activated receptor gamma in the placenta correlates to hyperglycemia in offspring at young adulthood after exposure to gestational diabetes mellitus
title_short Downregulation of peroxisome proliferator‐activated receptor gamma in the placenta correlates to hyperglycemia in offspring at young adulthood after exposure to gestational diabetes mellitus
title_sort downregulation of peroxisome proliferator‐activated receptor gamma in the placenta correlates to hyperglycemia in offspring at young adulthood after exposure to gestational diabetes mellitus
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6400209/
https://www.ncbi.nlm.nih.gov/pubmed/30187673
http://dx.doi.org/10.1111/jdi.12928
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