Reversal of New Onset Type 1 Diabetes by Oral Salmonella-Based Combination Therapy and Mediated by Regulatory T-Cells in NOD Mice

Autoimmune diseases such as type 1 diabetes (T1D) involve the loss of regulatory mechanisms resulting in increased tissue-specific cytotoxicity. The result is destruction of pancreatic insulin-producing β-cells and loss of glucose homeostasis. We are developing a novel oral vaccine using live attenu...

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Detalles Bibliográficos
Autores principales: Mbongue, Jacques C., Rawson, Jeffrey, Garcia, Pablo A., Gonzalez, Nelson, Cobb, Jacob, Kandeel, Fouad, Ferreri, Kevin, Husseiny, Mohamed I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6400227/
https://www.ncbi.nlm.nih.gov/pubmed/30863412
http://dx.doi.org/10.3389/fimmu.2019.00320

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