Cargando…
Fortified Milk Supplementation Improves Vitamin D Status, Grip Strength, and Maintains Bone Density in Chinese Premenopausal Women Living in Malaysia
This study compared the effects of a high-calcium vitamin D fortified milk with added FOS-Inulin versus regular milk on serum parathyroid hormone (PTH), vitamin D status, grip strength (GS), as well as bone density in Chinese premenopausal women over 52 weeks. Premenopausal women (n = 133), mean age...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Mary Ann Liebert, Inc., publishers
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6400229/ https://www.ncbi.nlm.nih.gov/pubmed/30842890 http://dx.doi.org/10.1089/biores.2018.0027 |
_version_ | 1783399919597387776 |
---|---|
author | Kruger, Marlena C. Chan, Yoke Mun Lau, ChinChin Lau, Lee Ting Chin, Yit Siew Kuhn-Sherlock, Barbara Schollum, Linda M. Todd, Joanne M. |
author_facet | Kruger, Marlena C. Chan, Yoke Mun Lau, ChinChin Lau, Lee Ting Chin, Yit Siew Kuhn-Sherlock, Barbara Schollum, Linda M. Todd, Joanne M. |
author_sort | Kruger, Marlena C. |
collection | PubMed |
description | This study compared the effects of a high-calcium vitamin D fortified milk with added FOS-Inulin versus regular milk on serum parathyroid hormone (PTH), vitamin D status, grip strength (GS), as well as bone density in Chinese premenopausal women over 52 weeks. Premenopausal women (n = 133), mean age 41 (±5.1) years were randomized into control (n = 66; regular milk at 500 mg calcium per day) or intervention (Int; n = 67; fortified milk at 1200 mg calcium, 15 μg vitamin D, and 4 g FOS-Inulin per day) groups. Assessments were at baseline, weeks 12, 24, 36, and 52 for changes in vitamin D status, levels of PTH, and GS. Bone mineral densities (BMDs) of the lumbar spine (LS), femoral neck (FN), and whole body (WB) were assessed at baseline and week 52 using GE Lunar iDEXA (GE Healthcare, Madison, WI). At baseline, WB lean mass was positively associated with LS BMD (r = 0.30, p < 0.001) and FN BMD (r = 0.33, p = 0.003). Baseline 25(OH) vitamin D3 levels were 48.6 and 53.2 nmol/L (p = 0.57), respectively, and after the 12 months at 60.8 nmol/L (Int) versus 55.0 nmol/L (controls; p < 0.05 for change from baseline for both groups; no difference between groups at week 52). PTH levels decreased in both groups compared to baseline (p < 0.001), with no significant difference between groups. WB bone mineral content (BMC) and FN Z-score increased significantly in the Int group (p = 0.024 and p = 0.008). GS was positively associated with body weight, increasing in both groups over 52 weeks. Fortified milk improved vitamin D status, WB BMC, and Z-score of the FN, while regular milk maintained BMD. In addition, vitamin D status and GS improved. |
format | Online Article Text |
id | pubmed-6400229 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Mary Ann Liebert, Inc., publishers |
record_format | MEDLINE/PubMed |
spelling | pubmed-64002292019-03-06 Fortified Milk Supplementation Improves Vitamin D Status, Grip Strength, and Maintains Bone Density in Chinese Premenopausal Women Living in Malaysia Kruger, Marlena C. Chan, Yoke Mun Lau, ChinChin Lau, Lee Ting Chin, Yit Siew Kuhn-Sherlock, Barbara Schollum, Linda M. Todd, Joanne M. Biores Open Access Original Research Article This study compared the effects of a high-calcium vitamin D fortified milk with added FOS-Inulin versus regular milk on serum parathyroid hormone (PTH), vitamin D status, grip strength (GS), as well as bone density in Chinese premenopausal women over 52 weeks. Premenopausal women (n = 133), mean age 41 (±5.1) years were randomized into control (n = 66; regular milk at 500 mg calcium per day) or intervention (Int; n = 67; fortified milk at 1200 mg calcium, 15 μg vitamin D, and 4 g FOS-Inulin per day) groups. Assessments were at baseline, weeks 12, 24, 36, and 52 for changes in vitamin D status, levels of PTH, and GS. Bone mineral densities (BMDs) of the lumbar spine (LS), femoral neck (FN), and whole body (WB) were assessed at baseline and week 52 using GE Lunar iDEXA (GE Healthcare, Madison, WI). At baseline, WB lean mass was positively associated with LS BMD (r = 0.30, p < 0.001) and FN BMD (r = 0.33, p = 0.003). Baseline 25(OH) vitamin D3 levels were 48.6 and 53.2 nmol/L (p = 0.57), respectively, and after the 12 months at 60.8 nmol/L (Int) versus 55.0 nmol/L (controls; p < 0.05 for change from baseline for both groups; no difference between groups at week 52). PTH levels decreased in both groups compared to baseline (p < 0.001), with no significant difference between groups. WB bone mineral content (BMC) and FN Z-score increased significantly in the Int group (p = 0.024 and p = 0.008). GS was positively associated with body weight, increasing in both groups over 52 weeks. Fortified milk improved vitamin D status, WB BMC, and Z-score of the FN, while regular milk maintained BMD. In addition, vitamin D status and GS improved. Mary Ann Liebert, Inc., publishers 2019-03-01 /pmc/articles/PMC6400229/ /pubmed/30842890 http://dx.doi.org/10.1089/biores.2018.0027 Text en © Marlena C. Kruger et al. 2019; Published by Mary Ann Liebert, Inc. This Open Access article is distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Research Article Kruger, Marlena C. Chan, Yoke Mun Lau, ChinChin Lau, Lee Ting Chin, Yit Siew Kuhn-Sherlock, Barbara Schollum, Linda M. Todd, Joanne M. Fortified Milk Supplementation Improves Vitamin D Status, Grip Strength, and Maintains Bone Density in Chinese Premenopausal Women Living in Malaysia |
title | Fortified Milk Supplementation Improves Vitamin D Status, Grip Strength, and Maintains Bone Density in Chinese Premenopausal Women Living in Malaysia |
title_full | Fortified Milk Supplementation Improves Vitamin D Status, Grip Strength, and Maintains Bone Density in Chinese Premenopausal Women Living in Malaysia |
title_fullStr | Fortified Milk Supplementation Improves Vitamin D Status, Grip Strength, and Maintains Bone Density in Chinese Premenopausal Women Living in Malaysia |
title_full_unstemmed | Fortified Milk Supplementation Improves Vitamin D Status, Grip Strength, and Maintains Bone Density in Chinese Premenopausal Women Living in Malaysia |
title_short | Fortified Milk Supplementation Improves Vitamin D Status, Grip Strength, and Maintains Bone Density in Chinese Premenopausal Women Living in Malaysia |
title_sort | fortified milk supplementation improves vitamin d status, grip strength, and maintains bone density in chinese premenopausal women living in malaysia |
topic | Original Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6400229/ https://www.ncbi.nlm.nih.gov/pubmed/30842890 http://dx.doi.org/10.1089/biores.2018.0027 |
work_keys_str_mv | AT krugermarlenac fortifiedmilksupplementationimprovesvitamindstatusgripstrengthandmaintainsbonedensityinchinesepremenopausalwomenlivinginmalaysia AT chanyokemun fortifiedmilksupplementationimprovesvitamindstatusgripstrengthandmaintainsbonedensityinchinesepremenopausalwomenlivinginmalaysia AT lauchinchin fortifiedmilksupplementationimprovesvitamindstatusgripstrengthandmaintainsbonedensityinchinesepremenopausalwomenlivinginmalaysia AT lauleeting fortifiedmilksupplementationimprovesvitamindstatusgripstrengthandmaintainsbonedensityinchinesepremenopausalwomenlivinginmalaysia AT chinyitsiew fortifiedmilksupplementationimprovesvitamindstatusgripstrengthandmaintainsbonedensityinchinesepremenopausalwomenlivinginmalaysia AT kuhnsherlockbarbara fortifiedmilksupplementationimprovesvitamindstatusgripstrengthandmaintainsbonedensityinchinesepremenopausalwomenlivinginmalaysia AT schollumlindam fortifiedmilksupplementationimprovesvitamindstatusgripstrengthandmaintainsbonedensityinchinesepremenopausalwomenlivinginmalaysia AT toddjoannem fortifiedmilksupplementationimprovesvitamindstatusgripstrengthandmaintainsbonedensityinchinesepremenopausalwomenlivinginmalaysia |