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Trpm4 ion channels in pre-Bötzinger complex interneurons are essential for breathing motor pattern but not rhythm

Inspiratory breathing movements depend on pre-Bötzinger complex (preBötC) interneurons that express calcium (Ca(2+))-activated nonselective cationic current (I(CAN)) to generate robust neural bursts. Hypothesized to be rhythmogenic, reducing I(CAN) is predicted to slow down or stop breathing; its co...

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Detalles Bibliográficos
Autores principales:	Picardo, Maria Cristina D., Sugimura, Yae K., Dorst, Kaitlyn E., Kallurkar, Prajkta S., Akins, Victoria T., Ma, Xingru, Teruyama, Ryoichi, Guinamard, Romain, Kam, Kaiwen, Saha, Margaret S., Del Negro, Christopher A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6400419/ https://www.ncbi.nlm.nih.gov/pubmed/30789900 http://dx.doi.org/10.1371/journal.pbio.2006094

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