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The connexin26 human mutation N14K disrupts cytosolic intersubunit interactions and promotes channel opening

A group of human mutations within the N-terminal (NT) domain of connexin 26 (Cx26) hemichannels produce aberrant channel activity, which gives rise to deafness and skin disorders, including keratitis-ichthyosis-deafness (KID) syndrome. Structural and functional studies indicate that the NT of connex...

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Detalles Bibliográficos
Autores principales:	Valdez Capuccino, Juan M., Chatterjee, Payal, García, Isaac E., Botello-Smith, Wesley M., Zhang, Han, Harris, Andrew L., Luo, Yun, Contreras, Jorge E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Rockefeller University Press 2019
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6400520/ https://www.ncbi.nlm.nih.gov/pubmed/30530766 http://dx.doi.org/10.1085/jgp.201812219

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