The tarantula toxin GxTx detains K(+) channel gating charges in their resting conformation

Allosteric ligands modulate protein activity by altering the energy landscape of conformational space in ligand–protein complexes. Here we investigate how ligand binding to a K(+) channel’s voltage sensor allosterically modulates opening of its K(+)-conductive pore. The tarantula venom peptide guang...

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Detalles Bibliográficos
Autores principales: Tilley, Drew C., Angueyra, Juan M., Eum, Kenneth S., Kim, Heesoo, Chao, Luke H., Peng, Anthony W., Sack, Jon T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6400525/
https://www.ncbi.nlm.nih.gov/pubmed/30397012
http://dx.doi.org/10.1085/jgp.201812213

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6400525/
https://www.ncbi.nlm.nih.gov/pubmed/30397012
http://dx.doi.org/10.1085/jgp.201812213

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