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The tarantula toxin GxTx detains K(+) channel gating charges in their resting conformation
Allosteric ligands modulate protein activity by altering the energy landscape of conformational space in ligand–protein complexes. Here we investigate how ligand binding to a K(+) channel’s voltage sensor allosterically modulates opening of its K(+)-conductive pore. The tarantula venom peptide guang...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Rockefeller University Press
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6400525/ https://www.ncbi.nlm.nih.gov/pubmed/30397012 http://dx.doi.org/10.1085/jgp.201812213 |