Small cell lung cancers made from scratch

In this issue of JEM, Chen et al. (https://doi.org/10.1084/jem.20181155) describe a new approach for the transformation of human pluripotent embryonic stem cells (hESCs) into neuroendocrine (NE) tumors of the lung closely resembling human small cell lung cancer (SCLC). Another recent study uses a di...

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Detalles Bibliográficos
Autores principales: Gazdar, Adi F., Minna, John D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2019
Materias:
News
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6400528/
https://www.ncbi.nlm.nih.gov/pubmed/30760489
http://dx.doi.org/10.1084/jem.20182216
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author Gazdar, Adi F.
Minna, John D.
author_facet Gazdar, Adi F.
Minna, John D.
author_sort Gazdar, Adi F.
collection PubMed
description In this issue of JEM, Chen et al. (https://doi.org/10.1084/jem.20181155) describe a new approach for the transformation of human pluripotent embryonic stem cells (hESCs) into neuroendocrine (NE) tumors of the lung closely resembling human small cell lung cancer (SCLC). Another recent study uses a different method to transform fully differentiated normal human cells into high-grade NE tumors (Park et al. 2018. Science. https://doi.org/10.1126/science.aat5749). These approaches and their models provide important new resources for developing diagnostic, preventative, and therapeutic approaches for high-grade NE tumors.
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spelling pubmed-64005282019-09-04 Small cell lung cancers made from scratch Gazdar, Adi F. Minna, John D. J Exp Med News In this issue of JEM, Chen et al. (https://doi.org/10.1084/jem.20181155) describe a new approach for the transformation of human pluripotent embryonic stem cells (hESCs) into neuroendocrine (NE) tumors of the lung closely resembling human small cell lung cancer (SCLC). Another recent study uses a different method to transform fully differentiated normal human cells into high-grade NE tumors (Park et al. 2018. Science. https://doi.org/10.1126/science.aat5749). These approaches and their models provide important new resources for developing diagnostic, preventative, and therapeutic approaches for high-grade NE tumors. Rockefeller University Press 2019-03-04 /pmc/articles/PMC6400528/ /pubmed/30760489 http://dx.doi.org/10.1084/jem.20182216 Text en © 2019 Gazdar and Minna http://www.rupress.org/terms/https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle News
Gazdar, Adi F.
Minna, John D.
Small cell lung cancers made from scratch
title Small cell lung cancers made from scratch
title_full Small cell lung cancers made from scratch
title_fullStr Small cell lung cancers made from scratch
title_full_unstemmed Small cell lung cancers made from scratch
title_short Small cell lung cancers made from scratch
title_sort small cell lung cancers made from scratch
topic News
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6400528/
https://www.ncbi.nlm.nih.gov/pubmed/30760489
http://dx.doi.org/10.1084/jem.20182216
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