rAAV-based brain slice culture models of Alzheimer’s and Parkinson’s disease inclusion pathologies

It has been challenging to produce ex vivo models of the inclusion pathologies that are hallmark pathologies of many neurodegenerative diseases. Using three-dimensional mouse brain slice cultures (BSCs), we have developed a paradigm that rapidly and robustly recapitulates mature neurofibrillary incl...

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Detalles Bibliográficos
Autores principales: Croft, Cara L., Cruz, Pedro E., Ryu, Daniel H., Ceballos-Diaz, Carolina, Strang, Kevin H., Woody, Brittany M., Lin, Wen-Lang, Deture, Michael, Rodríguez-Lebrón, Edgardo, Dickson, Dennis W., Chakrabarty, Paramita, Levites, Yona, Giasson, Benoit I., Golde, Todd E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6400529/
https://www.ncbi.nlm.nih.gov/pubmed/30770411
http://dx.doi.org/10.1084/jem.20182184

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