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Reactive species and pathogen antioxidant networks during phagocytosis

The generation of phagosomal cytotoxic reactive species (i.e., free radicals and oxidants) by activated macrophages and neutrophils is a crucial process for the control of intracellular pathogens. The chemical nature of these species, the reactions they are involved in, and the subsequent effects ar...

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Detalles Bibliográficos
Autores principales: Piacenza, Lucía, Trujillo, Madia, Radi, Rafael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6400530/
https://www.ncbi.nlm.nih.gov/pubmed/30792185
http://dx.doi.org/10.1084/jem.20181886
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author Piacenza, Lucía
Trujillo, Madia
Radi, Rafael
author_facet Piacenza, Lucía
Trujillo, Madia
Radi, Rafael
author_sort Piacenza, Lucía
collection PubMed
description The generation of phagosomal cytotoxic reactive species (i.e., free radicals and oxidants) by activated macrophages and neutrophils is a crucial process for the control of intracellular pathogens. The chemical nature of these species, the reactions they are involved in, and the subsequent effects are multifaceted and depend on several host- and pathogen-derived factors that influence their production rates and catabolism inside the phagosome. Pathogens rely on an intricate and synergistic antioxidant armamentarium that ensures their own survival by detoxifying reactive species. In this review, we discuss the generation, kinetics, and toxicity of reactive species generated in phagocytes, with a focus on the response of macrophages to internalized pathogens and concentrating on Mycobacterium tuberculosis and Trypanosoma cruzi as examples of bacterial and parasitic infection, respectively. The ability of pathogens to deal with host-derived reactive species largely depends on the competence of their antioxidant networks at the onset of invasion, which in turn can tilt the balance toward pathogen survival, proliferation, and virulence over redox-dependent control of infection.
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spelling pubmed-64005302019-09-04 Reactive species and pathogen antioxidant networks during phagocytosis Piacenza, Lucía Trujillo, Madia Radi, Rafael J Exp Med Reviews The generation of phagosomal cytotoxic reactive species (i.e., free radicals and oxidants) by activated macrophages and neutrophils is a crucial process for the control of intracellular pathogens. The chemical nature of these species, the reactions they are involved in, and the subsequent effects are multifaceted and depend on several host- and pathogen-derived factors that influence their production rates and catabolism inside the phagosome. Pathogens rely on an intricate and synergistic antioxidant armamentarium that ensures their own survival by detoxifying reactive species. In this review, we discuss the generation, kinetics, and toxicity of reactive species generated in phagocytes, with a focus on the response of macrophages to internalized pathogens and concentrating on Mycobacterium tuberculosis and Trypanosoma cruzi as examples of bacterial and parasitic infection, respectively. The ability of pathogens to deal with host-derived reactive species largely depends on the competence of their antioxidant networks at the onset of invasion, which in turn can tilt the balance toward pathogen survival, proliferation, and virulence over redox-dependent control of infection. Rockefeller University Press 2019-03-04 /pmc/articles/PMC6400530/ /pubmed/30792185 http://dx.doi.org/10.1084/jem.20181886 Text en © 2019 Piacenza et al. http://www.rupress.org/terms/https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Reviews
Piacenza, Lucía
Trujillo, Madia
Radi, Rafael
Reactive species and pathogen antioxidant networks during phagocytosis
title Reactive species and pathogen antioxidant networks during phagocytosis
title_full Reactive species and pathogen antioxidant networks during phagocytosis
title_fullStr Reactive species and pathogen antioxidant networks during phagocytosis
title_full_unstemmed Reactive species and pathogen antioxidant networks during phagocytosis
title_short Reactive species and pathogen antioxidant networks during phagocytosis
title_sort reactive species and pathogen antioxidant networks during phagocytosis
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6400530/
https://www.ncbi.nlm.nih.gov/pubmed/30792185
http://dx.doi.org/10.1084/jem.20181886
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