Cargando…

Human colon organoids reveal distinct physiologic and oncogenic Wnt responses

Constitutive Wnt activation upon loss of Adenoma polyposis coli (APC) acts as main driver of colorectal cancer (CRC). Targeting Wnt signaling has proven difficult because the pathway is crucial for homeostasis and stem cell renewal. To distinguish oncogenic from physiological Wnt activity, we have p...

Descripción completa

Detalles Bibliográficos
Autores principales:	Michels, Birgitta E., Mosa, Mohammed H., Grebbin, Britta M., Yepes, Diego, Darvishi, Tahmineh, Hausmann, Johannes, Urlaub, Henning, Zeuzem, Stefan, Kvasnicka, Hans M., Oellerich, Thomas, Farin, Henner F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Rockefeller University Press 2019
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6400532/ https://www.ncbi.nlm.nih.gov/pubmed/30792186 http://dx.doi.org/10.1084/jem.20180823

Ejemplares similares

Colorectal Cancer Organoid–Stroma Biobank Allows Subtype-Specific Assessment of Individualized Therapy Responses
por: Farin, Henner F., et al.
Publicado: (2023)

Dynamic Formation of Microvillus Inclusions During Enterocyte Differentiation in Munc18-2–Deficient Intestinal Organoids
por: Mosa, Mohammed H., et al.
Publicado: (2018)

Strategies for genetic manipulation of adult stem cell-derived organoids
por: Menche, Constantin, et al.
Publicado: (2021)

Cellular and Molecular Changes of Brain Metastases-Associated Myeloid Cells during Disease Progression and Therapeutic Response
por: Schulz, Michael, et al.
Publicado: (2020)

PBX1 as Pioneer Factor: A Case Still Open
por: Grebbin, Britta M., et al.
Publicado: (2017)

Strategies for Proteome-Wide Quantification of Glycosylation Macro- and Micro-Heterogeneity
por: Fang, Pan, et al.
Publicado: (2022)

AKT-dependent NOTCH3 activation drives tumor progression in a model of mesenchymal colorectal cancer
por: Varga, Julia, et al.
Publicado: (2020)

Oncogenic transformation of diverse gastrointestinal tissues in primary organoid culture
por: Li, Xingnan, et al.
Publicado: (2014)

Active elimination of intestinal cells drives oncogenic growth in organoids
por: Krotenberg Garcia, Ana, et al.
Publicado: (2021)

Oncogene-inducible organoids as a miniature platform to assess cancer characteristics
por: Mizutani, Tomohiro, et al.
Publicado: (2017)

Wnt status-dependent oncogenic role of BCL9 and BCL9L in hepatocellular carcinoma
por: Huge, Nicole, et al.
Publicado: (2019)

Identification and Characterization of FAM124B as a Novel Component of a CHD7 and CHD8 Containing Complex
por: Batsukh, Tserendulam, et al.
Publicado: (2012)

Quantitative Mass Spectrometric Profiling of Cancer-cell Proteomes Derived From Liquid and Solid Tumors
por: Bohnenberger, Hanibal, et al.
Publicado: (2015)

Interaction of viral oncogenic proteins with the Wnt signaling pathway
por: Khanizadeh, Sayyad, et al.
Publicado: (2018)

Elucidation of the SLP-65 phosphorylation state in activated B lymphocytes
por: Oellerich, T, et al.
Publicado: (2009)

Retromer Dependent Recycling of the Wnt Secretion Factor Wls Is Dispensable for Stem Cell Maintenance in the Mammalian Intestinal Epithelium
por: de Groot, Reinoud E. A., et al.
Publicado: (2013)

A streamlined pipeline for multiplexed quantitative site-specific N-glycoproteomics
por: Fang, Pan, et al.
Publicado: (2020)

The Notch and Wnt pathways regulate stemness and differentiation in human fallopian tube organoids
por: Kessler, Mirjana, et al.
Publicado: (2015)

Precardiac organoids form two heart fields via Bmp/Wnt signaling
por: Andersen, Peter, et al.
Publicado: (2018)

Aspirin Rescues Wnt-Driven Stem-like Phenotype in Human Intestinal Organoids and Increases the Wnt Antagonist Dickkopf-1
por: Dunbar, Karen, et al.
Publicado: (2020)

Wnt Pathway: An Integral Hub for Developmental and Oncogenic Signaling Networks
por: Sharma, Monica, et al.
Publicado: (2020)

Modulation of Wnt Signaling Enhances Inner Ear Organoid Development in 3D Culture
por: DeJonge, Rachel E., et al.
Publicado: (2016)

Shared effects of DISC1 disruption and elevated WNT signaling in human cerebral organoids
por: Srikanth, Priya, et al.
Publicado: (2018)

Spatiotemporal Gradient and Instability of Wnt Induce Heterogeneous Growth and Differentiation of Human Intestinal Organoids
por: Shin, Woojung, et al.
Publicado: (2020)

Wnt Activity and Cell Proliferation Are Coupled to Extracellular Vesicle Release in Multiple Organoid Models
por: Sándor, Gyöngyvér Orsolya, et al.
Publicado: (2021)

OTME-6. Deep sequencing reveals heterogeneity of brain metastasis-associated macrophages and microglia and uncovers their cell type-specific functions within the tumor microenvironment
por: Schulz, Michael, et al.
Publicado: (2021)

Commitment and oncogene-induced plasticity of human stem cell-derived pancreatic acinar and ductal organoids
por: Huang, Ling, et al.
Publicado: (2021)

WNT10A Plays an Oncogenic Role in Renal Cell Carcinoma by Activating WNT/β-catenin Pathway
por: Hsu, Ren-Jun, et al.
Publicado: (2012)

The oncogenic role of Wnt10a in colorectal cancer through activation of canonical Wnt/β-catenin signaling
por: Li, Jinlong, et al.
Publicado: (2019)

Ligand stimulation of CD95 induces activation of Plk3 followed by phosphorylation of caspase-8
por: Helmke, Christina, et al.
Publicado: (2016)

WNT6 is a novel oncogenic prognostic biomarker in human glioblastoma
por: Gonçalves, Céline S., et al.
Publicado: (2018)

Deep Annotation of Donated Chemical Probes (DCP) in Organotypic Human Liver Cultures and Patient-Derived Organoids from Tumor and Normal Colorectum
por: Tredup, Claudia, et al.
Publicado: (2023)

The cnidarian origin of the proto-oncogenes NF-κB/STAT and WNT-like oncogenic pathway drives the ctenophores (Review)
por: SINKOVICS, JOSEPH G.
Publicado: (2015)

The cnidarian origin of the proto-oncogenes NF-κB/STAT and WNT-like oncogenic pathway drives the ctenophores (Review)
por: Sinkovics, Joseph G.
Publicado: (2016)

Tailored tetravalent antibodies potently and specifically activate Wnt/Frizzled pathways in cells, organoids and mice
por: Tao, Yuyong, et al.
Publicado: (2019)

Small subset of Wnt‐activated cells is an initiator of regrowth in colorectal cancer organoids after irradiation
por: Endo, Hiroko, et al.
Publicado: (2020)

Oncogenic β-catenin and PIK3CA instruct network states and cancer phenotypes in intestinal organoids
por: Riemer, Pamela, et al.
Publicado: (2017)

Quantitative proteomics identifies biomarkers to distinguish pulmonary from head and neck squamous cell carcinomas by immunohistochemistry
por: Richter, Annika, et al.
Publicado: (2021)

Allometric Scaling of physiologically-relevant organoids
por: Magliaro, Chiara, et al.
Publicado: (2019)

Nuclear S6K1 Enhances Oncogenic Wnt Signaling by Inducing Wnt/β-Catenin Transcriptional Complex Formation
por: Lee, Min Gyu, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_bn9lutblhqi6l4tvj6987h2kpv