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Human colon organoids reveal distinct physiologic and oncogenic Wnt responses

Constitutive Wnt activation upon loss of Adenoma polyposis coli (APC) acts as main driver of colorectal cancer (CRC). Targeting Wnt signaling has proven difficult because the pathway is crucial for homeostasis and stem cell renewal. To distinguish oncogenic from physiological Wnt activity, we have p...

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Detalles Bibliográficos
Autores principales:	Michels, Birgitta E., Mosa, Mohammed H., Grebbin, Britta M., Yepes, Diego, Darvishi, Tahmineh, Hausmann, Johannes, Urlaub, Henning, Zeuzem, Stefan, Kvasnicka, Hans M., Oellerich, Thomas, Farin, Henner F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Rockefeller University Press 2019
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6400532/ https://www.ncbi.nlm.nih.gov/pubmed/30792186 http://dx.doi.org/10.1084/jem.20180823

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