EDA fibronectin–TLR4 axis sustains megakaryocyte expansion and inflammation in bone marrow fibrosis

The fibronectin EDA isoform (EDA FN) is instrumental in fibrogenesis but, to date, its expression and function in bone marrow (BM) fibrosis have not been explored. We found that mice constitutively expressing the EDA domain (EIIIA(+/+)), but not EDA knockout mice, are more prone to develop BM fibros...

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Detalles Bibliográficos
Autores principales: Malara, Alessandro, Gruppi, Cristian, Abbonante, Vittorio, Cattaneo, Daniele, De Marco, Luigi, Massa, Margherita, Iurlo, Alessandra, Gianelli, Umberto, Balduini, Carlo L., Tira, Maria E., Muro, Andrès F., Chauhan, Anil K., Rosti, Vittorio, Barosi, Giovanni, Balduini, Alessandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6400533/
https://www.ncbi.nlm.nih.gov/pubmed/30733282
http://dx.doi.org/10.1084/jem.20181074

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