ATM is activated by ATP depletion and modulates mitochondrial function through NRF1

Ataxia-telangiectasia (A-T) is an autosomal recessive disease caused by mutation of the ATM gene and is characterized by loss of cerebellar Purkinje cells, neurons with high physiological activity and dynamic ATP demands. Here, we show that depletion of ATP generates reactive oxygen species that act...

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Detalles Bibliográficos
Autores principales: Chow, Hei-Man, Cheng, Aifang, Song, Xuan, Swerdel, Mavis R., Hart, Ronald P., Herrup, Karl
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6400560/
https://www.ncbi.nlm.nih.gov/pubmed/30642892
http://dx.doi.org/10.1083/jcb.201806197

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6400560/
https://www.ncbi.nlm.nih.gov/pubmed/30642892
http://dx.doi.org/10.1083/jcb.201806197

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