Sense and sensibility: ATM oxygen stress signaling manages brain cell energetics

The ataxia-telangiectasia mutated (ATM) gene regulates DNA damage repair, oxidative stress, and mitochondrial processes. In this issue, Chow et al. (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201806197) connects ATM’s oxidative stress response functions to the sensing of metabolic ATP energetic...

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Detalles Bibliográficos
Autor principal: Schlacher, Katharina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2019
Materias:
Commentaries
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6400571/
https://www.ncbi.nlm.nih.gov/pubmed/30782782
http://dx.doi.org/10.1083/jcb.201901050
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author Schlacher, Katharina
author_facet Schlacher, Katharina
author_sort Schlacher, Katharina
collection PubMed
description The ataxia-telangiectasia mutated (ATM) gene regulates DNA damage repair, oxidative stress, and mitochondrial processes. In this issue, Chow et al. (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201806197) connects ATM’s oxidative stress response functions to the sensing of metabolic ATP energetics distinctively important in high energy–demanding Purkinje brain cells, which could explain the most distinct A-T patient feature, cerebellar ataxia.
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spelling pubmed-64005712019-09-04 Sense and sensibility: ATM oxygen stress signaling manages brain cell energetics Schlacher, Katharina J Cell Biol Commentaries The ataxia-telangiectasia mutated (ATM) gene regulates DNA damage repair, oxidative stress, and mitochondrial processes. In this issue, Chow et al. (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201806197) connects ATM’s oxidative stress response functions to the sensing of metabolic ATP energetics distinctively important in high energy–demanding Purkinje brain cells, which could explain the most distinct A-T patient feature, cerebellar ataxia. Rockefeller University Press 2019-03-04 /pmc/articles/PMC6400571/ /pubmed/30782782 http://dx.doi.org/10.1083/jcb.201901050 Text en © 2019 Schlacher http://www.rupress.org/terms/https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Commentaries
Schlacher, Katharina
Sense and sensibility: ATM oxygen stress signaling manages brain cell energetics
title Sense and sensibility: ATM oxygen stress signaling manages brain cell energetics
title_full Sense and sensibility: ATM oxygen stress signaling manages brain cell energetics
title_fullStr Sense and sensibility: ATM oxygen stress signaling manages brain cell energetics
title_full_unstemmed Sense and sensibility: ATM oxygen stress signaling manages brain cell energetics
title_short Sense and sensibility: ATM oxygen stress signaling manages brain cell energetics
title_sort sense and sensibility: atm oxygen stress signaling manages brain cell energetics
topic Commentaries
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6400571/
https://www.ncbi.nlm.nih.gov/pubmed/30782782
http://dx.doi.org/10.1083/jcb.201901050
work_keys_str_mv AT schlacherkatharina senseandsensibilityatmoxygenstresssignalingmanagesbraincellenergetics

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