Heterochromatic foci and transcriptional repression by an unstructured MET-2/SETDB1 co-factor LIN-65

The segregation of the genome into accessible euchromatin and histone H3K9-methylated heterochromatin helps silence repetitive elements and tissue-specific genes. In Caenorhabditis elegans, MET-2, the homologue of mammalian SETDB1, catalyzes H3K9me1 and me2, yet like SETDB1, its regulation is enigma...

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Detalles Bibliográficos
Autores principales: Delaney, Colin E., Methot, Stephen P., Guidi, Micol, Katic, Iskra, Gasser, Susan M., Padeken, Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6400574/
https://www.ncbi.nlm.nih.gov/pubmed/30737265
http://dx.doi.org/10.1083/jcb.201811038

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6400574/
https://www.ncbi.nlm.nih.gov/pubmed/30737265
http://dx.doi.org/10.1083/jcb.201811038

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