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KRAS G12V Mutation is an Adverse Prognostic Factor of Chinese Gastric Cancer Patients
This study aims to investigate the molecular characteristics of Chinese gastric cancer patients. In our study, the KRAS, BRAF, and PIK3CA mutation status of 485 GC patients were analyzed by Sanger sequencing. Kaplan-Meier analysis was used to plot survival curves according to different genotypes. Th...
| Autores principales: | , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Ivyspring International Publisher
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6400811/ https://www.ncbi.nlm.nih.gov/pubmed/30854087 http://dx.doi.org/10.7150/jca.27899 |
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| author | Fu, Xin-Hui Chen, Zhi-Ting Wang, Wen-Hui Fan, Xin-Juan Huang, Yan Wu, Xiao-Bin Huang, Jing-Lin Wang, Jing-Xuan Lin, Han-Jie Tan, Xiao-Li Wang, Lei Wang, Jian-Ping |
| author_facet | Fu, Xin-Hui Chen, Zhi-Ting Wang, Wen-Hui Fan, Xin-Juan Huang, Yan Wu, Xiao-Bin Huang, Jing-Lin Wang, Jing-Xuan Lin, Han-Jie Tan, Xiao-Li Wang, Lei Wang, Jian-Ping |
| author_sort | Fu, Xin-Hui |
| collection | PubMed |
| description | This study aims to investigate the molecular characteristics of Chinese gastric cancer patients. In our study, the KRAS, BRAF, and PIK3CA mutation status of 485 GC patients were analyzed by Sanger sequencing. Kaplan-Meier analysis was used to plot survival curves according to different genotypes. The results show that the frequency of KRAS, BRAF and PIK3CA mutations were 4.1%, 1.2% and 3.5%, respectively. BRAF mutations were significantly concentrated in stage III and IV gastric cancer (P=0.009). KRAS G12V mutation carriers have much shorter OS than other mutation carriers and wild-type group patients (P=0.013). In conclusion, only the KRAS G12V mutation has an adverse effect on patient survival. |
| format | Online Article Text |
| id | pubmed-6400811 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2019 |
| publisher | Ivyspring International Publisher |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-64008112019-03-08 KRAS G12V Mutation is an Adverse Prognostic Factor of Chinese Gastric Cancer Patients Fu, Xin-Hui Chen, Zhi-Ting Wang, Wen-Hui Fan, Xin-Juan Huang, Yan Wu, Xiao-Bin Huang, Jing-Lin Wang, Jing-Xuan Lin, Han-Jie Tan, Xiao-Li Wang, Lei Wang, Jian-Ping J Cancer Research Paper This study aims to investigate the molecular characteristics of Chinese gastric cancer patients. In our study, the KRAS, BRAF, and PIK3CA mutation status of 485 GC patients were analyzed by Sanger sequencing. Kaplan-Meier analysis was used to plot survival curves according to different genotypes. The results show that the frequency of KRAS, BRAF and PIK3CA mutations were 4.1%, 1.2% and 3.5%, respectively. BRAF mutations were significantly concentrated in stage III and IV gastric cancer (P=0.009). KRAS G12V mutation carriers have much shorter OS than other mutation carriers and wild-type group patients (P=0.013). In conclusion, only the KRAS G12V mutation has an adverse effect on patient survival. Ivyspring International Publisher 2019-01-29 /pmc/articles/PMC6400811/ /pubmed/30854087 http://dx.doi.org/10.7150/jca.27899 Text en © Ivyspring International Publisher This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/). See http://ivyspring.com/terms for full terms and conditions. |
| spellingShingle | Research Paper Fu, Xin-Hui Chen, Zhi-Ting Wang, Wen-Hui Fan, Xin-Juan Huang, Yan Wu, Xiao-Bin Huang, Jing-Lin Wang, Jing-Xuan Lin, Han-Jie Tan, Xiao-Li Wang, Lei Wang, Jian-Ping KRAS G12V Mutation is an Adverse Prognostic Factor of Chinese Gastric Cancer Patients |
| title | KRAS G12V Mutation is an Adverse Prognostic Factor of Chinese Gastric Cancer Patients |
| title_full | KRAS G12V Mutation is an Adverse Prognostic Factor of Chinese Gastric Cancer Patients |
| title_fullStr | KRAS G12V Mutation is an Adverse Prognostic Factor of Chinese Gastric Cancer Patients |
| title_full_unstemmed | KRAS G12V Mutation is an Adverse Prognostic Factor of Chinese Gastric Cancer Patients |
| title_short | KRAS G12V Mutation is an Adverse Prognostic Factor of Chinese Gastric Cancer Patients |
| title_sort | kras g12v mutation is an adverse prognostic factor of chinese gastric cancer patients |
| topic | Research Paper |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6400811/ https://www.ncbi.nlm.nih.gov/pubmed/30854087 http://dx.doi.org/10.7150/jca.27899 |
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