Cargando…

The Upregulation of Trophinin-Associated Protein (TROAP) Predicts a Poor Prognosis in Hepatocellular Carcinoma

Purpose: Trophinin-associated protein (TROAP) is a cytoplasmic protein that plays a significant role in the processes of embryo transplantation and microtubule regulation. However, the relevant survival analysis and cancer progression analysis have not yet been reported. Methods: Eighteen matched pa...

Descripción completa

Detalles Bibliográficos
Autores principales: Hu, Hao, Xu, Liang, Chen, Yan, Luo, Shao-Ju, Wu, Ying-zi, Xu, Shi-Hua, Liu, Meng-Ting, Lin, Fen, Mei, Yan, Yang, Qin, Qiang, Yuan-yuan, Lin, You-wu, Deng, Yuan-jiang, Lin, Tong, Sha, Yong-qiang, Huang, Bi-Jun, Zhang, Shi-Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6400818/
https://www.ncbi.nlm.nih.gov/pubmed/30854102
http://dx.doi.org/10.7150/jca.26666
_version_ 1783400024927895552
author Hu, Hao
Xu, Liang
Chen, Yan
Luo, Shao-Ju
Wu, Ying-zi
Xu, Shi-Hua
Liu, Meng-Ting
Lin, Fen
Mei, Yan
Yang, Qin
Qiang, Yuan-yuan
Lin, You-wu
Deng, Yuan-jiang
Lin, Tong
Sha, Yong-qiang
Huang, Bi-Jun
Zhang, Shi-Jun
author_facet Hu, Hao
Xu, Liang
Chen, Yan
Luo, Shao-Ju
Wu, Ying-zi
Xu, Shi-Hua
Liu, Meng-Ting
Lin, Fen
Mei, Yan
Yang, Qin
Qiang, Yuan-yuan
Lin, You-wu
Deng, Yuan-jiang
Lin, Tong
Sha, Yong-qiang
Huang, Bi-Jun
Zhang, Shi-Jun
author_sort Hu, Hao
collection PubMed
description Purpose: Trophinin-associated protein (TROAP) is a cytoplasmic protein that plays a significant role in the processes of embryo transplantation and microtubule regulation. However, the relevant survival analysis and cancer progression analysis have not yet been reported. Methods: Eighteen matched pairs of tumor and adjacent non-tumor samples were evaluated to detect the TROAP mRNA level. Immunohistochemistry (IHC) was used to evaluate the TROAP expression in 108 hepatocellular carcinoma patients who underwent surgical resection. Meanwhile, data from the TCGA database was statistically evaluated. Results: In the present study, we detected a significant increase in the TROAP mRNA level in tumor tissues when compared with adjacent non-tumor tissues. Moreover, the upregulation of TROAP was associated with increased serum AFP and GGT; the greater the tumor number was, the larger the tumor size, differentiation grade, and cancer embolus in clinical analysis. In HCC patients, elevated TROAP expression in the primary tumor was positively related to clinical severity, such as poor overall survival and disease-free survival. In addition, both univariate and multivariate survival analysis validated that TROAP expression was a promising independent risk factor for overall survival and disease-free survival in HCC patients. Furthermore, the results derived from the analysis of data from the TCGA database were consistent with previous results. Altogether, our results show that TROAP is a novel crucial regulator of HCC progression and is a potential therapeutic biomarker for HCC patients. Conclusions: Elevated TROAP expression predicted a poor prognosis, and TROAP may serve as a potential biomarker for application in oncotherapy.
format Online
Article
Text
id pubmed-6400818
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Ivyspring International Publisher
record_format MEDLINE/PubMed
spelling pubmed-64008182019-03-08 The Upregulation of Trophinin-Associated Protein (TROAP) Predicts a Poor Prognosis in Hepatocellular Carcinoma Hu, Hao Xu, Liang Chen, Yan Luo, Shao-Ju Wu, Ying-zi Xu, Shi-Hua Liu, Meng-Ting Lin, Fen Mei, Yan Yang, Qin Qiang, Yuan-yuan Lin, You-wu Deng, Yuan-jiang Lin, Tong Sha, Yong-qiang Huang, Bi-Jun Zhang, Shi-Jun J Cancer Research Paper Purpose: Trophinin-associated protein (TROAP) is a cytoplasmic protein that plays a significant role in the processes of embryo transplantation and microtubule regulation. However, the relevant survival analysis and cancer progression analysis have not yet been reported. Methods: Eighteen matched pairs of tumor and adjacent non-tumor samples were evaluated to detect the TROAP mRNA level. Immunohistochemistry (IHC) was used to evaluate the TROAP expression in 108 hepatocellular carcinoma patients who underwent surgical resection. Meanwhile, data from the TCGA database was statistically evaluated. Results: In the present study, we detected a significant increase in the TROAP mRNA level in tumor tissues when compared with adjacent non-tumor tissues. Moreover, the upregulation of TROAP was associated with increased serum AFP and GGT; the greater the tumor number was, the larger the tumor size, differentiation grade, and cancer embolus in clinical analysis. In HCC patients, elevated TROAP expression in the primary tumor was positively related to clinical severity, such as poor overall survival and disease-free survival. In addition, both univariate and multivariate survival analysis validated that TROAP expression was a promising independent risk factor for overall survival and disease-free survival in HCC patients. Furthermore, the results derived from the analysis of data from the TCGA database were consistent with previous results. Altogether, our results show that TROAP is a novel crucial regulator of HCC progression and is a potential therapeutic biomarker for HCC patients. Conclusions: Elevated TROAP expression predicted a poor prognosis, and TROAP may serve as a potential biomarker for application in oncotherapy. Ivyspring International Publisher 2019-01-29 /pmc/articles/PMC6400818/ /pubmed/30854102 http://dx.doi.org/10.7150/jca.26666 Text en © Ivyspring International Publisher This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Research Paper
Hu, Hao
Xu, Liang
Chen, Yan
Luo, Shao-Ju
Wu, Ying-zi
Xu, Shi-Hua
Liu, Meng-Ting
Lin, Fen
Mei, Yan
Yang, Qin
Qiang, Yuan-yuan
Lin, You-wu
Deng, Yuan-jiang
Lin, Tong
Sha, Yong-qiang
Huang, Bi-Jun
Zhang, Shi-Jun
The Upregulation of Trophinin-Associated Protein (TROAP) Predicts a Poor Prognosis in Hepatocellular Carcinoma
title The Upregulation of Trophinin-Associated Protein (TROAP) Predicts a Poor Prognosis in Hepatocellular Carcinoma
title_full The Upregulation of Trophinin-Associated Protein (TROAP) Predicts a Poor Prognosis in Hepatocellular Carcinoma
title_fullStr The Upregulation of Trophinin-Associated Protein (TROAP) Predicts a Poor Prognosis in Hepatocellular Carcinoma
title_full_unstemmed The Upregulation of Trophinin-Associated Protein (TROAP) Predicts a Poor Prognosis in Hepatocellular Carcinoma
title_short The Upregulation of Trophinin-Associated Protein (TROAP) Predicts a Poor Prognosis in Hepatocellular Carcinoma
title_sort upregulation of trophinin-associated protein (troap) predicts a poor prognosis in hepatocellular carcinoma
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6400818/
https://www.ncbi.nlm.nih.gov/pubmed/30854102
http://dx.doi.org/10.7150/jca.26666
work_keys_str_mv AT huhao theupregulationoftrophininassociatedproteintroappredictsapoorprognosisinhepatocellularcarcinoma
AT xuliang theupregulationoftrophininassociatedproteintroappredictsapoorprognosisinhepatocellularcarcinoma
AT chenyan theupregulationoftrophininassociatedproteintroappredictsapoorprognosisinhepatocellularcarcinoma
AT luoshaoju theupregulationoftrophininassociatedproteintroappredictsapoorprognosisinhepatocellularcarcinoma
AT wuyingzi theupregulationoftrophininassociatedproteintroappredictsapoorprognosisinhepatocellularcarcinoma
AT xushihua theupregulationoftrophininassociatedproteintroappredictsapoorprognosisinhepatocellularcarcinoma
AT liumengting theupregulationoftrophininassociatedproteintroappredictsapoorprognosisinhepatocellularcarcinoma
AT linfen theupregulationoftrophininassociatedproteintroappredictsapoorprognosisinhepatocellularcarcinoma
AT meiyan theupregulationoftrophininassociatedproteintroappredictsapoorprognosisinhepatocellularcarcinoma
AT yangqin theupregulationoftrophininassociatedproteintroappredictsapoorprognosisinhepatocellularcarcinoma
AT qiangyuanyuan theupregulationoftrophininassociatedproteintroappredictsapoorprognosisinhepatocellularcarcinoma
AT linyouwu theupregulationoftrophininassociatedproteintroappredictsapoorprognosisinhepatocellularcarcinoma
AT dengyuanjiang theupregulationoftrophininassociatedproteintroappredictsapoorprognosisinhepatocellularcarcinoma
AT lintong theupregulationoftrophininassociatedproteintroappredictsapoorprognosisinhepatocellularcarcinoma
AT shayongqiang theupregulationoftrophininassociatedproteintroappredictsapoorprognosisinhepatocellularcarcinoma
AT huangbijun theupregulationoftrophininassociatedproteintroappredictsapoorprognosisinhepatocellularcarcinoma
AT zhangshijun theupregulationoftrophininassociatedproteintroappredictsapoorprognosisinhepatocellularcarcinoma
AT huhao upregulationoftrophininassociatedproteintroappredictsapoorprognosisinhepatocellularcarcinoma
AT xuliang upregulationoftrophininassociatedproteintroappredictsapoorprognosisinhepatocellularcarcinoma
AT chenyan upregulationoftrophininassociatedproteintroappredictsapoorprognosisinhepatocellularcarcinoma
AT luoshaoju upregulationoftrophininassociatedproteintroappredictsapoorprognosisinhepatocellularcarcinoma
AT wuyingzi upregulationoftrophininassociatedproteintroappredictsapoorprognosisinhepatocellularcarcinoma
AT xushihua upregulationoftrophininassociatedproteintroappredictsapoorprognosisinhepatocellularcarcinoma
AT liumengting upregulationoftrophininassociatedproteintroappredictsapoorprognosisinhepatocellularcarcinoma
AT linfen upregulationoftrophininassociatedproteintroappredictsapoorprognosisinhepatocellularcarcinoma
AT meiyan upregulationoftrophininassociatedproteintroappredictsapoorprognosisinhepatocellularcarcinoma
AT yangqin upregulationoftrophininassociatedproteintroappredictsapoorprognosisinhepatocellularcarcinoma
AT qiangyuanyuan upregulationoftrophininassociatedproteintroappredictsapoorprognosisinhepatocellularcarcinoma
AT linyouwu upregulationoftrophininassociatedproteintroappredictsapoorprognosisinhepatocellularcarcinoma
AT dengyuanjiang upregulationoftrophininassociatedproteintroappredictsapoorprognosisinhepatocellularcarcinoma
AT lintong upregulationoftrophininassociatedproteintroappredictsapoorprognosisinhepatocellularcarcinoma
AT shayongqiang upregulationoftrophininassociatedproteintroappredictsapoorprognosisinhepatocellularcarcinoma
AT huangbijun upregulationoftrophininassociatedproteintroappredictsapoorprognosisinhepatocellularcarcinoma
AT zhangshijun upregulationoftrophininassociatedproteintroappredictsapoorprognosisinhepatocellularcarcinoma