Regulation of Polycomb Repression by O-GlcNAcylation: Linking Nutrition to Epigenetic Reprogramming in Embryonic Development and Cancer

Epigenetic modifications are major actors of early embryogenesis and carcinogenesis and are sensitive to nutritional environment. In recent years, the nutritional sensor O-GlcNAcylation has been recognized as a key regulator of chromatin remodeling. In this review, we summarize and discuss recent cl...

Descripción completa

Detalles Bibliográficos
Autores principales: Decourcelle, Amélie, Leprince, Dominique, Dehennaut, Vanessa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6400832/
https://www.ncbi.nlm.nih.gov/pubmed/30873122
http://dx.doi.org/10.3389/fendo.2019.00117
_version_ 1783400027234762752
author Decourcelle, Amélie
Leprince, Dominique
Dehennaut, Vanessa
author_facet Decourcelle, Amélie
Leprince, Dominique
Dehennaut, Vanessa
author_sort Decourcelle, Amélie
collection PubMed
description Epigenetic modifications are major actors of early embryogenesis and carcinogenesis and are sensitive to nutritional environment. In recent years, the nutritional sensor O-GlcNAcylation has been recognized as a key regulator of chromatin remodeling. In this review, we summarize and discuss recent clues that OGT and O-GlcNAcylation intimately regulate the functions of the Polycomb group proteins at different levels especially during Drosophila melanogaster embryonic development and in human cancer cell lines. These observations define an additional connection between nutrition and epigenetic reprogramming associated to embryonic development and cancer.
format Online
Article
Text
id pubmed-6400832
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-64008322019-03-14 Regulation of Polycomb Repression by O-GlcNAcylation: Linking Nutrition to Epigenetic Reprogramming in Embryonic Development and Cancer Decourcelle, Amélie Leprince, Dominique Dehennaut, Vanessa Front Endocrinol (Lausanne) Endocrinology Epigenetic modifications are major actors of early embryogenesis and carcinogenesis and are sensitive to nutritional environment. In recent years, the nutritional sensor O-GlcNAcylation has been recognized as a key regulator of chromatin remodeling. In this review, we summarize and discuss recent clues that OGT and O-GlcNAcylation intimately regulate the functions of the Polycomb group proteins at different levels especially during Drosophila melanogaster embryonic development and in human cancer cell lines. These observations define an additional connection between nutrition and epigenetic reprogramming associated to embryonic development and cancer. Frontiers Media S.A. 2019-02-27 /pmc/articles/PMC6400832/ /pubmed/30873122 http://dx.doi.org/10.3389/fendo.2019.00117 Text en Copyright © 2019 Decourcelle, Leprince and Dehennaut. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Decourcelle, Amélie
Leprince, Dominique
Dehennaut, Vanessa
Regulation of Polycomb Repression by O-GlcNAcylation: Linking Nutrition to Epigenetic Reprogramming in Embryonic Development and Cancer
title Regulation of Polycomb Repression by O-GlcNAcylation: Linking Nutrition to Epigenetic Reprogramming in Embryonic Development and Cancer
title_full Regulation of Polycomb Repression by O-GlcNAcylation: Linking Nutrition to Epigenetic Reprogramming in Embryonic Development and Cancer
title_fullStr Regulation of Polycomb Repression by O-GlcNAcylation: Linking Nutrition to Epigenetic Reprogramming in Embryonic Development and Cancer
title_full_unstemmed Regulation of Polycomb Repression by O-GlcNAcylation: Linking Nutrition to Epigenetic Reprogramming in Embryonic Development and Cancer
title_short Regulation of Polycomb Repression by O-GlcNAcylation: Linking Nutrition to Epigenetic Reprogramming in Embryonic Development and Cancer
title_sort regulation of polycomb repression by o-glcnacylation: linking nutrition to epigenetic reprogramming in embryonic development and cancer
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6400832/
https://www.ncbi.nlm.nih.gov/pubmed/30873122
http://dx.doi.org/10.3389/fendo.2019.00117
work_keys_str_mv AT decourcelleamelie regulationofpolycombrepressionbyoglcnacylationlinkingnutritiontoepigeneticreprogramminginembryonicdevelopmentandcancer
AT leprincedominique regulationofpolycombrepressionbyoglcnacylationlinkingnutritiontoepigeneticreprogramminginembryonicdevelopmentandcancer
AT dehennautvanessa regulationofpolycombrepressionbyoglcnacylationlinkingnutritiontoepigeneticreprogramminginembryonicdevelopmentandcancer

Ejemplares similares