Cargando…
Efficient Treatment of Sporothrix globosa Infection Using the Antibody Elicited by Recombinant Phage Nanofibers
Antifungal therapy is used to treat sporotrichosis. However, there are several limitations in this therapy, such as development of drug resistance and potential health risks including liver injury. The purpose of our study was to evaluate the antifungal efficacy of antibody against the hybrid phage...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6400886/ https://www.ncbi.nlm.nih.gov/pubmed/30873031 http://dx.doi.org/10.3389/fphar.2019.00160 |
_version_ | 1783400042098327552 |
---|---|
author | Chen, Feng Jiang, Rihua Dong, Shuai Yan, Bailing |
author_facet | Chen, Feng Jiang, Rihua Dong, Shuai Yan, Bailing |
author_sort | Chen, Feng |
collection | PubMed |
description | Antifungal therapy is used to treat sporotrichosis. However, there are several limitations in this therapy, such as development of drug resistance and potential health risks including liver injury. The purpose of our study was to evaluate the antifungal efficacy of antibody against the hybrid phage nanofibers displaying KPVQHALLTPLGLDR (phage-KR) in a fungal-infected mouse model. In this study, we extracte an antibody against hybrid phage nanofibers (phage-KR) from immunized mice and passively inoculate Sporothrix globosa (S. globosa) infected mice. The study shows that the antibody exhibits efficient inhibition efficacy of the S. globosa infection, including reduction of the progressive fungi colonizing, increase of animal survival rate and relief of organ inflammation in the mice. The results indicate that antibody against phage-KR may act as a potential strategy for safe and efficient treatment of S. globosa infections. |
format | Online Article Text |
id | pubmed-6400886 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-64008862019-03-14 Efficient Treatment of Sporothrix globosa Infection Using the Antibody Elicited by Recombinant Phage Nanofibers Chen, Feng Jiang, Rihua Dong, Shuai Yan, Bailing Front Pharmacol Pharmacology Antifungal therapy is used to treat sporotrichosis. However, there are several limitations in this therapy, such as development of drug resistance and potential health risks including liver injury. The purpose of our study was to evaluate the antifungal efficacy of antibody against the hybrid phage nanofibers displaying KPVQHALLTPLGLDR (phage-KR) in a fungal-infected mouse model. In this study, we extracte an antibody against hybrid phage nanofibers (phage-KR) from immunized mice and passively inoculate Sporothrix globosa (S. globosa) infected mice. The study shows that the antibody exhibits efficient inhibition efficacy of the S. globosa infection, including reduction of the progressive fungi colonizing, increase of animal survival rate and relief of organ inflammation in the mice. The results indicate that antibody against phage-KR may act as a potential strategy for safe and efficient treatment of S. globosa infections. Frontiers Media S.A. 2019-02-27 /pmc/articles/PMC6400886/ /pubmed/30873031 http://dx.doi.org/10.3389/fphar.2019.00160 Text en Copyright © 2019 Chen, Jiang, Dong and Yan. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Pharmacology Chen, Feng Jiang, Rihua Dong, Shuai Yan, Bailing Efficient Treatment of Sporothrix globosa Infection Using the Antibody Elicited by Recombinant Phage Nanofibers |
title | Efficient Treatment of Sporothrix globosa Infection Using the Antibody Elicited by Recombinant Phage Nanofibers |
title_full | Efficient Treatment of Sporothrix globosa Infection Using the Antibody Elicited by Recombinant Phage Nanofibers |
title_fullStr | Efficient Treatment of Sporothrix globosa Infection Using the Antibody Elicited by Recombinant Phage Nanofibers |
title_full_unstemmed | Efficient Treatment of Sporothrix globosa Infection Using the Antibody Elicited by Recombinant Phage Nanofibers |
title_short | Efficient Treatment of Sporothrix globosa Infection Using the Antibody Elicited by Recombinant Phage Nanofibers |
title_sort | efficient treatment of sporothrix globosa infection using the antibody elicited by recombinant phage nanofibers |
topic | Pharmacology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6400886/ https://www.ncbi.nlm.nih.gov/pubmed/30873031 http://dx.doi.org/10.3389/fphar.2019.00160 |
work_keys_str_mv | AT chenfeng efficienttreatmentofsporothrixglobosainfectionusingtheantibodyelicitedbyrecombinantphagenanofibers AT jiangrihua efficienttreatmentofsporothrixglobosainfectionusingtheantibodyelicitedbyrecombinantphagenanofibers AT dongshuai efficienttreatmentofsporothrixglobosainfectionusingtheantibodyelicitedbyrecombinantphagenanofibers AT yanbailing efficienttreatmentofsporothrixglobosainfectionusingtheantibodyelicitedbyrecombinantphagenanofibers |