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Application of Locked Nucleic Acid Oligonucleotides for siRNA Preclinical Bioanalytics

Despite the exquisite potential of siRNA as a therapeutic, the mechanism(s) responsible for the robust indirect exposure-response relationships have not been fully elucidated. To understand the siRNA properties linked to potent activity, requires the disposition of siRNA to be characterized. A techn...

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Detalles Bibliográficos
Autores principales:	Thayer, Mai B., Lade, Julie M., Doherty, David, Xie, Fang, Basiri, Babak, Barnaby, Omar S., Bala, Noor S., Rock, Brooke M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6401054/ https://www.ncbi.nlm.nih.gov/pubmed/30837588 http://dx.doi.org/10.1038/s41598-019-40187-4

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