Molecular imaging HDACs class IIa expression-activity and pharmacologic inhibition in intracerebral glioma models in rats using PET/CT/(MRI) with [(18)F]TFAHA

HDAC class IIa enzymes (HDAC4, 5, 7, 9) are important for glioma progression, invasion, responses to TMZ and radiotherapy, and prognosis. In this study, we demonstrated the efficacy of PET/CT/(MRI) with [(18)F]TFAHA for non-invasive and quantitative imaging of HDAC class IIa expression-activity in i...

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Detalles Bibliográficos
Autores principales: Laws, Maxwell T., Bonomi, Robin E., Kamal, Swatabdi, Gelovani, David J., Llaniguez, Jeremy, Potukutchi, Shreya, Lu, Xin, Mangner, Thomas, Gelovani, Juri G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6401080/
https://www.ncbi.nlm.nih.gov/pubmed/30837601
http://dx.doi.org/10.1038/s41598-019-40054-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6401080/
https://www.ncbi.nlm.nih.gov/pubmed/30837601
http://dx.doi.org/10.1038/s41598-019-40054-2

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