Gene expression analysis reveals early dysregulation of disease pathways and links Chmp7 to pathogenesis of spinal and bulbar muscular atrophy

Spinal and bulbar muscular atrophy (SBMA) results from a CAG repeat expansion within the androgen receptor gene (AR). It is unclear why motor neurons selectively degenerate and there are currently no treatments for this debilitating disease. To uncover the causative genes and pathways involved in mo...

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Detalles Bibliográficos
Autores principales: Malik, Bilal, Devine, Helen, Patani, Rickie, La Spada, Albert R., Hanna, Michael G., Greensmith, Linda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6401132/
https://www.ncbi.nlm.nih.gov/pubmed/30837566
http://dx.doi.org/10.1038/s41598-019-40118-3

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