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Extensive reprogramming of the nascent transcriptome during iPSC to hepatocyte differentiation

Hepatocyte-like cells (HLCs) derived from induced pluripotent stem cells (iPSCs) provide a renewable source of cells for drug discovery, disease modelling and cell-based therapies. Here, by using GRO-Seq we provide the first genome-wide analysis of the nascent RNAs in iPSCs, HLCs and primary hepatoc...

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Detalles Bibliográficos
Autores principales:	Viiri, Leena E., Rantapero, Tommi, Kiamehr, Mostafa, Alexanova, Anna, Oittinen, Mikko, Viiri, Keijo, Niskanen, Henri, Nykter, Matti, Kaikkonen, Minna U., Aalto-Setälä, Katriina
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6401154/ https://www.ncbi.nlm.nih.gov/pubmed/30837492 http://dx.doi.org/10.1038/s41598-019-39215-0

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