Oral Gavage of Ginger Nanoparticle-Derived Lipid Vectors Carrying Dmt1 siRNA Blunts Iron Loading in Murine Hereditary Hemochromatosis

Nanoparticles (NPs) have been utilized to deliver drugs to the intestinal epithelium in vivo. Moreover, NPs derived from edible plants are less toxic than synthetic NPs. Here, we utilized ginger NP-derived lipid vectors (GDLVs) in a proof-of-concept investigation to test the hypothesis that inhibiti...

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Detalles Bibliográficos
Autores principales: Wang, Xiaoyu, Zhang, Mingzhen, Flores, Shireen R.L., Woloshun, Regina R., Yang, Chunhua, Yin, Liangjie, Xiang, Ping, Xu, Xiaodong, Garrick, Michael D., Vidyasagar, Sadasivan, Merlin, Didier, Collins, James F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2019
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6401192/
https://www.ncbi.nlm.nih.gov/pubmed/30713087
http://dx.doi.org/10.1016/j.ymthe.2019.01.003

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